smad4 gene; 4. methylation; Presenting Author: HAILONG CAO Additional Authors: BANGMAO WANG Corresponding Author: BANGMAO WANG Affiliations: Department of Gastroenterology and Hepatology Objective: Sporadic selleck inhibitor fundic gland polyps (FGPs) are now the most common gastric polyps. Some studies reported that proton pump inhibitor (PPI) therapy seemed to be associated with FGPs. However, data were controversial. We aimed to identify whether FGPs were induced by PPI therapy in our population. Methods: Consecutive patients with FGPs detected were retrospectively analyzed. Data
including patients’ age, sex, symptoms, H. pylori infection, history of PPI use, and the polyps were documented. Each patient was compared with two randomly selected age and sex matched controls in the same period. Results: A total of 328 patients were diagnosed as FGPs in 23 047 patients who underwent routine esophagogastroduodenoscopy. The mean age was 55.12 ± 12.61 years, and 75.91% were women. H. pylori infection was detected in 64 patients with FGPs (22.30%), and 224 patients without FGPs (42.26%, P < 0.001). Overall, a total of 54 patients with FGPs (16.46%), Protein Tyrosine Kinase inhibitor and 136 patients without FGPs (20.73%) received PPI therapy (P = 0.073). According to different duration of PPI use, no significant difference in PPI intake
was found among the subgroups. The PPI use was also similar, regardless of ages, sexes, 上海皓元 polyps number, and H. pylori infection. Conclusion: Sporadic FGPs may not be induced by PPI therapy, and unnecessary anxieties ought to be avoided. Key Word(s): 1. Fundic gland polyps; 2. PPIs; Presenting Author: JIN ZUO Additional Authors: GUOBIN HE, GENGZHENG HUANG, QIN ZHANG, WEN MING Corresponding Author: JIN ZUO, GUOBIN HE Affiliations: Department of Gastroenterology, the Affiliated Hospital of North Sichuan Medical College; Department of Gastroenterology, the Affiliated Hospital of North Sichuan Medical College Objective: To explore the impact of cognitive factors related to causes, symptoms, treatments, prognosis on health-related quality of life and severity of symptoms
in patients with functional dyspepsia. Methods: We enrolled 182 consecutive outpatients (52.7% female patients, mean age 40.5 years) with functional dyspepsia based on the Rome III criteria. Patients were interviewed and evaluated by the Cognitive Questionnaire, the Nepean Dyspepsia Index and the Functional Dyspepsia Severity Scale. Multiple linear regression models were built for Nepean Dyspepsia Index, dyspepsia Severity Scale and anxiety to assess the independent factors associated with the cognitions in patients with functional dyspepsia. Results: FD patients believed that different somatisation symptoms induced by different diseases distinguishing from FD, dyspeptic symptoms affected by dietary, economy and emotion were reported by 52.7%, 80.2%, 23.1%, 37.3%, respectively.