In the controlled portion of the study, itch scores improved in patients taking sertraline, but worsened in patients taking placebo (P = 0.009).64 Sertraline is extensively metabolized by the liver and therefore a lower dose or less frequent dosing should be used in patients with hepatic impairment; however, it is not affected

by renal impairment or hemodialysis. Contraindications to sertraline usage include use of selleck chemicals monoamine oxidase inhibitors (MOA) in the past 14 days, concurrent use of pimozide or oral sertraline concentrate with disulfiram. As previously mentioned sertraline is well tolerated among patients suffering from cholestatic pruritus, some uncommon side effects

that may occur among patients receiving sertraline for the management of cholestatic pruritus include nausea, dizziness, increased bowel frequency, visual hallucinations and increased fatigue.64 Sertraline at a dose of 75–100 mg/day (increased gradually by 25 mg increments every 4–5 days from a starting dose of 25 mg) is effective and well tolerated in managing cholestatic pruritus. Other FDA-approved Drug Library screening treatments.  Evidence regarding the benefit of antihistamines in cholestatic pruritus is lacking even for commonly used medications such as diphenhydramine (Benadryl).65 Studies have shown that antihistamines, which also have anti-muscarinergic effects, although commonly prescribed for treatment of pruritus, may worsen the common symptoms of dry mouth and dry eyes in patients with PBC.63 Albumin dialysis using molecular adsorbent recirculating system (MARS) is a therapeutic option for treating resistant 上海皓元医药股份有限公司 pruritus in cholestasis. An analysis of

patients with resistant cholestasis treated with MARS in three centers concluded that albumin dialysis was effective in reducing pruritus in 75% of patients and was similar in patients with different diseases and independent of dialysis or perfusion.66 Evidence remains lacking and randomized controlled trials are needed to confirm effectiveness and safety. A small review of only two case reports suggests that plasmapheresis is a safe therapeutic option with rapid effectiveness in alleviating pruritic symptoms in pregnant patients with PBC.67 This evidence is insufficient to recommend the implication of plasmapheresis for the management of patients with cholestatic pruritus. It is worth noting that intractable pruritus can become an indication for liver transplantation even if no evidence of cellular hepatic or biliary abnormalities are present.68 Evidence is lacking for typical antihistamines including diphenhydramine. Farnesoid X receptors.