Furthermore, alternative pathways distinct from the GSTT1 system and probably associated with PTH catabolism in the liver may lead to de novo AIH [3, 4]. Regarding the concerns raised by Aguilera et al. about our study presentation, we carefully checked the references in the Introduction and Discussion sections one by one, and we regard them as appropriate and fully matched to the points discussed in the text. Perhaps the only point that we agree with is that reference 7 does not support the second sentence

in paragraph 2 of the Introduction section, since it refers to an older study. We regret to have omitted some other important references, as those indicated by Aguilera, but the journal’s word limit for case reports did not allow us to cite all of them. We also had to include some data about de novo AIH after RO4929097 mw LT for primary biliary cirrhosis, which was the underlying pathology in the index case (references 8, 13, 15). Furthermore, our paper was reviewed by three independent reviewers, and none of them raised any concern about mismatched or inappropriate references. References 1. Aguilera I, Nuñez-Roldan A (2012) Comments on Anagnostis et al.: De novo autoimmune hepatitis associated with PTH(1-34) and PTH(1-84) administration

for severe osteoporosis in a liver transplant patient. Osteoporos Int. doi:10.​1007/​s00198-012-1926-9 2. Anagnostis P, Efstathiadou ZA, Akriviadis E, Hytiroglou selleck products P, Kita M (2011) De novo autoimmune hepatitis associated with Adenosine PTH(1-34) and PTH(1-84) administration for severe osteoporosis in a liver transplant patient. Osteoporos

Int. doi:10.​1007/​s00198-011-1848-y 3. Segre GV, Perkins AS, Witters LA, Potts J Jr (1981) Metabolism of parathyroid hormone by isolated rat Kupffer cells and hepatocytes. J Clin Invest 67:449–457PubMedCrossRef 4. Mitnick MA, Grey A, Masiukiewicz U, Bartkiewicz M, Rios-Velez L, Friedman S, Xu L, Horowitz MC, Insogna K (2001) Parathyroid hormone induces hepatic production of bioactive interleukin-6 and its soluble receptor. Am J Physiol Endocrinol Metab 280:E405–E412PubMed”
“Introduction Severe vitamin D deficiency, caused by reduced sun exposure, leads to osteomalacia (adults)/rickets (children) resulting from defective skeletal mineralisation. Milder vitamin D deficiency, termed ‘insufficiency’, may also affect skeletal health in the elderly by reducing bone mineral density (BMD) and increasing fracture risk due to secondary hyperparathyroidism, in the absence of mineralisation defects [1]. If also applicable in childhood, vitamin D requirements in children would need to be set to prevent insufficiency rather than vitamin D deficiency and rickets [2]. Vitamin D insufficiency in children may be relatively common.