Height was not included in any BMAD regression models as it was already adjusted in BMAD calculations. Table 4 and Figs. 1 and 2 show the relationships Temsirolimus order between age and BMC, BMD, and BMAD by race/ethnicity after adjusting for weight and height using nonlinear equation and smoothing techniques. The R 2 values for different nonlinear regressions ranged from 0.95 to 0.99, which indicates the good fit of the models. Both SBMC and SBMD did not reach an asymptote for blacks and Hispanics and mTOR phosphorylation continued to increase with age. Whites’ SBMD peaked at the age of 30. FNBMC peaked at the age of 22 among blacks and between 29 and 31 years among Hispanics. The respective peak for FNBMD was 21 and 20 years. However, MM-102 manufacturer whites did not gain BMC or BMD at the femoral neck and their values continued to decrease with age. The scenarios for SBMAD and

FNBMAD are similar to those of SBMD and FNBMD (Fig. 2). Fig. 1 a Spine bone mineral content (BMC; g) and b femoral neck BMC by race/ethnicity. Solid line shows fitted values Fig. 2 a Spine bone mineral density (BMD; g/cm2), b femoral neck BMD, c spine bone mineral apparent density

(BMAD; g/cm3), and d femoral neck BMAD by race/ethnicity. Solid line shows fitted values Table 4 Bone mineral density and bone mineral content at lumbar spine and femoral neck by age and race/ethnicity adjusted by weight and Thalidomide height Age Bone mineral content (g) Bone mineral density (g/cm2) Number of Women Lumbar spine Femoral neck Lumbar spine Femoral neck Black White Hispanic Black White Hispanic Black White Hispanic Black White Hispanic Black White Hispanic 16 16 11 14 57.50 59.19 51.63 4.27 4.31 3.90 1.0478 1.0154 0.9734 0.9547 0.9141 0.8977 17 10 11 9 58.15 59.08 52.17 4.30 4.29 3.91 1.0566 1.0197 0.9812 0.9585 0.9117 0.8971 18 9 15 13 58.92 59.02 52.70 4.33 4.26 3.93 1.0663 1.0235 0.9898 0.9633 0.9087 0.8975 19 9 17 12 59.68 59.04 53.22 4.35 4.24 3.95 1.0756 1.0268 0.9984 0.9672 0.9052 0.8982 20 11 6 12 60.42 59.11 53.73 4.37 4.21 3.96 1.0847 1.0302 1.0067 0.9705 0.9015 0.8987 21 20 22 23 60.95 59.19 54.20 4.38 4.19 3.98 1.0927 1.0338 1.0142 0.9731 0.8984 0.8985 22 18 18 14 60.98 59.35 54.59 4.37 4.17 3.98 1.0980 1.0380 1.0205 0.9728 0.8963 0.8973 23 12 11 18 60.85 59.59 54.97 4.34 4.16 3.98 1.1012 1.0421 1.0260 0.9690 0.8943 0.8957 24 12 15 15 60.90 59.83 55.40 4.32 4.15 3.99 1.1052 1.0459 1.0319 0.9656 0.8918 0.8945 25 19 12 12 61.