Oral Dis 2009, 15:162–169.PubMedCrossRef 23. Friess H, Zhu Z, Liard V, Shi X, Shrikhande SV, Wang L, Lieb K, Korc M, Palma C, Zimmermann A, Reubi JC, Büchler MW: Neurokinin-1 receptor expression and its potential effects on tumor growth in human pancreatic cancer. Lab Invest 2003, 83:731–742.PubMed 24. Payan DG, Brewster DR, Missirian-Bastian A-1210477 clinical trial A, Goetzl EJ: Substance P recognition by a subset of human T

lymphocytes. J Clin Invest 1984, 74:1532–1539.PubMedCrossRef 25. Luo W, Sharif TR, Sharif M: Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogenactivated protein kinase signaling pathway. Cancer Res 1996, 56:4983–4991.PubMed 26. Irrissuto C, Maggi CA, Goso C: Role of NK-1 and NK-2 tachykinin receptor antagonism on the growth of human breast carcinoma cell line MDA-MB-231. Anticancer Drugs 2005, 16:1083–1089.PubMedCrossRef 27. Lang K, Drell TL, Lindecke A, Niggemann B, Kaltschmidt

C, Zaenker KS, Entschladen F: Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int J Cancer 2004, 112:231–238.PubMedCrossRef 28. Muñoz M, Rosso M, Coveñas R: The NK-1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on human pancreatic cancer cell lines. Lett Drug Des Discov 2006, 3:323–329.CrossRef 29. Muñoz M, Rosso M, Coveñas R: NK-1 receptor antagonists as new anti-tumoural learn more agents: action on human neuroblastoma cell lines. In Focus on neuroblastoma research. Edited by: Fernandes JA. New York: Nova Science; 2007:31–56. 30. Muñoz M, Rosso M, Soult JA, Coveñas R: Antitumoural action of neurokinin-1 receptor antagonists on human brain cancer cell lines. In Brain cancer: therapy and surgical intervention. Edited by: Yang AV. New York: Nova Science; 2006:45–75. 31. Rozengurt E: Neuropeptides as cellular growth factors: role of multiple signalling pathways. Eur J Clin Invest 1991, 21:123–134.PubMedCrossRef 32. Ishizuka J, Beauchamp RD, Townsend CM Jr, Greeley GH Jr, Thompson JC: Receptor-mediated autocrine growth-stimulatory

effect of 5-hydroxytryptamine on cultured human pancreatic carcinoid cells. J Cell Physiol 1992, 150:1–7.PubMedCrossRef 33. Millar JBA, Rozengurt Thalidomide E: Bombesin enhancement of cAMP accumulation in Swiss 3T3 cells: evidence of a dual mechanism of action. J Cell Physiol 1988, 137:214–222.PubMedCrossRef 34. Carroll JS, Brown M: Estrogen receptor target gene: an evolving concept. Mol Endocrinol 2006, 20:1707–1714.PubMedCrossRef 35. van Biesen T, Hawes BE, Raymond JR, Luttrell LM, Koch WJ, Lefkowitz RJ: G(o)-protein alpha-subunits activate mitogenactivated protein kinase via a novel protein kinase C-dependent mechanism. J Biol Chem 1996, 271:1266–1269.PubMedCrossRef 36. Zhang Z, Kumar R, Selleck CBL0137 Santen RJ, Song RX: The role of adapter protein Shc in estrogen non-genomic action.