grisea); and the oomycete P. sojae. Scope of the PAMGO terms The initial aim of the PAMGO consortium was to create terms associated with plant-pathogen interactions. However, it soon became apparent that creating more inclusive terms that were appropriate to both prokaryotic and eukaryotic microbes, to both plant and Everolimus solubility dmso animal hosts, and for describing the whole range of intimate relationships

between them (encompassing mutualism through parasitism), would better capture commonalities across diverse gene products involved in microbe-host interactions. After all, microbes of every domain face the same challenges in initiating an intimate association with a host. All must initially attach to the Rapamycin clinical trial host and breach a barrier or enter through openings to gain access to a nutritional source; all must suppress, evade, or tolerate host defenses for successful invasion. In addition, CSF-1R inhibitor it is known that microbes share strategies for invading a host, whether plant or animal. For example, bacterial pathogens of both

plants and animals utilize the type III protein secretion machinery to inject effectors into host cells [9]. (Bacterial secretion systems, including the type III is reviewed in this supplement [10].) Some of those effectors target defensive signal transduction pathways common to both plant and animal hosts. Furthermore, pathogens as diverse as oomycetes (attacking plants) and protozoans (attacking animals) have been shown to share a common targeting domain in their secreted proteins that enter host cells [11, 12]. Therefore we created an initial set of general

terms to describe microbial activities common across the systems described above. Some of those general terms can be seen in Figure 1. In a different paper of this Gene Ontology-focused supplement, Lindeberg et al. [13] detail the GO annotation of type III effectors from both a plant pathogen, Pseudomonas syringae pv tomato DC3000 (PtoDC3000), and the animal pathogen Escherichia coli, emphasizing the similarities and differences in CYTH4 processes employed by these diverse pathogens in manipulating host defenses. A similar analysis reported in another paper in this series [14] extends the comparison to effectors of eukaryotic pathogens from diverse taxa, including oomycetes, fungi, and nematodes. The power of ontology-based annotation to capture common themes in such diverse pathogens is well illustrated in these two mini reviews. Figure 1 Parent and child terms associated with “” GO:0044403 symbiosis, encompassing mutualism through parasitism”". “”GO:0044403 symbiosis, encompassing mutualism through parasitism”", was developed by the PAMGO consortium to emphasize the continuum of microbe-host relationships.