26 mM for Mc-Coy cell line. The compound exhibited weak antioxidant potential, with an RC(50) value of 0.262 click here mg mL(-1) and high antimicrobial effects against Staphylococcus epidermidis and Candida kefyr.”
“Objective: Otitis media is a multifactorial disease where genetic background may have an important role. For genome-wide association studies, it is important to understand the degree of heritability. The objective of this study was to estimate the heritability of recurrent acute otitis media and
chronic otitis media with effusion.
Methods: Children operated because of recurrent or chronic otitis media at the Helsinki University Central Hospital, Finland, as well as their families were recruited during 2008-2009. A cohort of 2436 subjects was enrolled consisting of 1279 children and their parents. The study subjects answered a questionnaire concerning their otitis media history and treatment, as well as tobacco exposure, allergy and asthma history. Heritability estimates were calculated for recurrent acute, chronic and any episodes of otitis media using software especially GKT137831 designed for estimating heritability in family cohorts.
Results: Altogether
901 subjects suffered from recurrent otitis media and 559 from chronic otitis media with effusion. The heritability estimates in our cohort were 38.5% for recurrent (P = 7.3 x 10(-9)), 22.1% for chronic (P = 4.6 x 10(-3)) and 47.8% for any otitis media (P = 1.5 x 10(-11)).
Conclusions: Our results
demonstrate a moderately strong and statistically significant genetic component for both recurrent acute otitis media and chronic otitis media with effusion. These results highlight the importance of unraveling the genetic factors for otitis media that are still poorly known. (C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“Shear wave induced resonance elastography (SWIRE) is proposed for deep venous thrombosis (DVT) elasticity assessment. This new imaging technique takes advantage of properly polarized shear waves to induce resonance of a confined mechanical heterogeneity. Realistic phantoms (n = 9) of DVT total and partial clot occlusions with elasticities from 406 to 3561 Pa Hydroxylase inhibitor were built for in vitro experiments. An ex vivo study was also performed to evaluate the elasticity of two fresh porcine venous thrombi in a pig model. Transient shear waves at 45-205 Hz were generated by the vibration of a rigid plate (plane wavefront) or by a needle to simulate a radiation pressure on a line segment (cylindrical wavefront). Induced propagation of shear waves was imaged with an ultrafast ultrasound scanner and a finite element method was developed to simulate tested experimental conditions. An inverse problem was then formulated considering the first resonance frequency of the DVT inclusion.