001). The mean measured IOP was 9.95 mm Hg +/- 3.01 (SD) before CXL, 11.40 +/- 2.89 mm Hg at 6 months, and 11.35 +/- 3.38 mm Hg at 12 months. The change in IOP measurements at both postoperative examinations was not correlated with patient age, preoperative pachymetry, or preoperative keratometry readings.
CONCLUSION: After riboflavin UVA CXL in eyes with keratoconus, there was
a significant increase learn more in IOP measured by GAT that was probably caused by an increase in corneal rigidity.”
“Background: The World Health Organization endorses the use of artemisinin-based combination therapy for treatment of acute uncomplicated falciparum malaria in the second and third trimesters of pregnancy. However, the effects of pregnancy on the pharmacokinetics of artemisinin derivatives, such as artesunate (AS), are poorly understood. In this analysis, the population pharmacokinetics of oral AS, and its active metabolite dihydroartemisinin PS-341 manufacturer (DHA), were studied in pregnant and non-pregnant women at the Kingasani Maternity
Clinic in the DRC.
Methods: Data were obtained from 26 pregnant women in the second (22 – 26 weeks) or the third (32 – 36 weeks) trimester of pregnancy and from 25 non-pregnant female controls. All subjects received 200 mg AS. Plasma AS and DHA were measured using a validated LC-MS method. Estimates for pharmacokinetic and variability parameters were obtained through nonlinear mixed effects modelling.
Results: A simultaneous parent-metabolite model was developed consisting of mixed zero-order, lagged first-order absorption of AS, a one-compartment model for AS, and a one-compartment model for DHA. Complete conversion of AS to DHA was assumed. The model displayed satisfactory goodness-of-fit, stability, and predictive ability. Apparent clearance (CL/F) and volume of distribution (V/F) estimates, with 95% bootstrap confidence intervals, were as follows: 195 L (139-285
L) for AS V/F, 895 L/h (788-1045 L/h) for AS CL/F, 91.4 L (78.5-109 L) for DHA V/F, and 64.0 L/h (55.1-75.2 L/h) for DHA CL/F. The effect of pregnancy on DHA CL/F was determined to be significant, with a pregnancy-associated increase in DHA CL/F of 42.3% (19.7 – 72.3%).
Conclusions: In this analysis, pharmacokinetic p38 MAPK apoptosis modelling suggests that pregnant women have accelerated DHA clearance compared to non-pregnant women receiving orally administered AS. These findings, in conjunction with a previous non-compartmental analysis of the modelled data, provide further evidence that higher AS doses would be required to maintain similar DHA levels in pregnant women as achieved in non-pregnant controls.”
“The diffusion of levofloxacin mesylate (MSALVFX) within agarose hydrogels was investigated by an improved refractive-index method. The diffusion coefficient of MSALVFX in infinite dilution (D(0)) was obtained as 4.01 x 10(-6) cm(2)/s (25 degrees C) through extrapolation according to Kohlrausch’s law.