Then, we focused our studies on NAC modulation of LOX activity. Results: LOX activity was increased on day 9 and peaked 14 days after BLM administration, Akt assay while TGF-beta(1) protein peaked on day 9. Interestingly, NAC treatment for 14 days from day 0 reversed LOX activity to normal levels and increased GSH levels in the lung of BLM-dosed rats. Consistently, NAC partially attenuated pulmonary
fibrosis and inhibited TGF-beta(1) and alpha-SMA expression in this model. Conclusions: Our study supports a novel mechanism of NAC alleviating IPF by inhibition of LOX activity via elevation of lung GSH in BLM-induced pulmonary fibrosis. The TGF-beta(1)/alpha-SMA pathway may also play an important role in modulation of LOX activity. Copyright (C) 2012 S. Karger AG, Basel”
“Four new ionone and ionone glycosides (1-4), and a new monoterpene (5), together with 10 known analogues (6-15), were isolated from the air-dried roots of Rehmannia glutinosa. The structures of these compounds were elucidated on the basis of spectroscopic check details data analysis. Furthermore, in in vitro assays, compound 3 (10M) exhibited moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage.
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“Four new triterpenoids,
2-O-acetyl-3-O-(4-O-acetyl)–l-arabinopyranosylmaslinic acid (1), 2-O-acetyl-3-O-(3-O-acetyl)–l-arabinopyranosylmaslinic acid (2), 2-O-acetyl-3-O-(3,4-O-diacetyl)–l-arabinopyranosylmaslinic acid (3), and 3-O-(3-O-acetyl)–l-arabinopyranosyloleanolic acid (4), together with six known triterpenoids, 3-O-(4-O-acetyl)–l-arabinopyranosyloleanolic acid (5), maslinic acid (6), 2-O-acetylmaslinic MEK162 ic50 acid (7), 3-O-acetylmaslinic acid (8), betulinic acid (9), and 2-hydroxy-3-O-acetylbetulinic acid (10), were isolated from
the EtOAc extract of Garcinia hanburyi resin. Their structures were elucidated by analysis of the spectroscopic data and chemical methods.”
“Lymphangiomas are localized malformations of the lymphatic system that most commonly occur in the head and neck. However, less than 1% of all lymphangiomas are confined to the mediastinum. The standard treatment has been surgical excision, but the involvement of vital structures in the area local to the lymphangioma makes total excision virtually impossible in most cases. To our knowledge, there has been no report of mediastinal lymphangioma treated with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). We report here the first case of safe, effective treatment of a very large mediastinal lymphangioma using EBUS-TBNA in a 29-year-old man. Copyright (C) 2012 S. Karger AG, Basel”
“From the leaves and twigs of Psychotria henryi, a new dimeric indole alkaloid, named psychohenin, was isolated, whose structure was elucidated on the basis of extensive spectroscopic analysis.