The relationship

between large artery characteristics and pathogenesis of OA has not been investigated and was the aim of this study.

Design: Large artery characteristics (i.e., aortic stiffness, brachial and central blood pressure (BP) variables) and bone marrow lesions (BMLs; measured by magnetic resonance imaging as a surrogate index of OA) were recorded in 208 participants (aged 63 +/- 7 years; mean +/- SD) with symptomatic knee OA. Relationships between find more large artery characteristics and BML were assessed by multiple regression adjusting for age, sex and body mass index.

Results: There was a high prevalence of BML presence in the study population (70%), but no significant difference between participants with and without BML for all large artery and BP variables (P>0.05 all). Furthermore, there were no significant relationships between BML size and aortic stiffness (r = -0.033, P = 0.71), central pulse pressure (r = 0.028, P = 0.74), augmentation index (r = 0.125, P = 0.14), brachial pulse pressure (r = 0.005, P = 0.95) or brachial systolic BP (r = -0.066, P = 0.44). When participants

were stratified according to high or low aortic stiffness, there was no significant difference between groups regarding the proportion of those with a BML (64% vs 70% respectively; P = 0.69).

Conclusions: INCB028050 cell line Variables indicative of large artery characteristics are not significantly correlated with BML size or presence in people with symptomatic knee OA. Thus, large artery characteristics may not have a causative influence in the development of OA, but this needs to be confirmed in prospective studies. Crown Copyright (C) 2013 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. All rights reserved.”
“The antiradical power of the methanol extracts of olive pomace (Taggiasca cultivar) achieved by Gamma-secretase inhibitor high-pressure-high-temperature reactor were investigated using ABTS(center dot+) and DPPH center dot assays. The highest antioxidant activity was quantified at 90 min of contact time and 180 degrees C of extraction temperature

(64.19 +/- 0.16 mu g(TE)L(-1) and 15.80 +/- 0.62 mu g(DPPH) mu L-extract(-1)). The extract with high-antioxidant power resulted to be effective to counteract key aspects of cellular oxidation sensitive mechanisms and inflammation associated to vascular diseases. A linear correlation (p < 0.05) between total polyphenol contents and antioxidant capacity was given by the ABTS(center dot+) method (R-2 = 0.9184) and DPPH assay (R-2 = 0.7062).”
“Objective: Proteoglycan (PG) loss and surface roughening, early signs of osteoarthritis (OA), are likely preceded by softening of the ground substance and the collagen network. Insight in their relative importance to progression of OA may assist the development of treatment strategies for early OA.