Most AEs of abnormal peripheral sensation were rated as mild (95%) and the majority (65%) resolved before study completion. At Week 8, overall knee pain and SGA improved from baseline by a mean (+/-standard error) of -12.8 (+/-1.78) and 8.0 (+/-1.66), respectively. Similar improvements occurred for WOMAC subscales.

Conclusions: Repeated injections of tanezumab in patients GM6001 with moderate to severe knee OA provide continued pain relief and improved function with a low incidence of side effects. Additional studies to define the efficacy and

duration of pain reduction and to provide a more complete assessment of long-term safety are warranted. (C) 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.”
“The objective of this study was to investigate differences on the endometrial immunoexpression of type I IFN receptor subunit 1 (IFNAR1) and oxytocin receptor (OTR) during the time of maternal recognition of pregnancy in sheep, when oestrus is synchronized with either prostaglandin analogues (group

PG) or conventional progestagens (group P). Plasma progesterone was measured from day 0 to 21 post-coitus (pc) (day 0 = day of oestrus). Immunohistochemistry was performed in samples of uterine horns from pregnant sheep on days 9pc, 13pc, 15pc, 17pc and 21pc to locate IFNAR1 and OTR expression in different endometrial compartments. Mean Elafibranor nmr levels of plasma progesterone were different between treatments, obtaining higher levels in the PG group than in the P group (p < 0.05). Comparing days of pregnancy, IFNAR1 protein expression was different in the luminal epithelium (LE) (p < 0.05), while OTR was different in the LE and in the superficial glandular epithelium (SG) (p < 0.05). Temporal variation on the expression of both proteins from day 9pc to 21pc has been evidenced. IFNAR1 and OTR expression did not show significant differences between treatments. However, P5091 the response observed in the endometrium was highly inconsistent

when prostaglandin analogues were used. Therefore, the protocol based on prostaglandin analogues still needs to be optimized before being considered as a better alternative to progestagens for oestrous synchronization in sheep.”
“In the present work, lignin isolation and physicochemical features from oil palm fronds (OPF) black liquor using Kraft, soda and organosolv pulping have been studied. The characterization of lignin samples by means of FTIR, H-1 and C-13 NMR has shown that different types of hydroxyl functional groups were obtained from different delignification processes. It was revealed that the lignin samples contained substantial amounts of non-condensed guaiacyl and syringyl unit with fewer p-hydroxyphenyl units. The GSH molar ratio of Kraft, soda and organosolv lignin was assigned to 26:51:21,21:49:30 and 23:67:10, respectively, upon quantification.