Diabetic rats (n = 8) were treated with MCF extract (400 mg kg(-1)
day(-1)) or glibenclamide (5 mg kg(-1)) for 28 days. Control rats (n = 11) and untreated diabetic rats (n = click here 8) received only water. Fasting glucose, serum insulin (by ELISA) and beta-cell function (HOMA % B by homeostasis model assessment) were measured. beta- and alpha-cells were identified by immunostaining, nuclei by DAPI, and beta-cell size and number by morphometry. Significant improvement of fasting blood glucose, serum insulin and beta-cell function was observed with the MCF extract for the diabetic rat model. The islet size, total beta-cell area and number of beta-cells were increased to almost double in the diabetic rats treated with MCF extract as compared to the untreated diabetic rats. The number of alpha-cells
did not change significantly. Insulin granules in beta-cells were notably reduced in diabetic islets as compared to control islets. However, extract-treated diabetic rat beta-cells were abundant with insulin granules, which was comparable to non-diabetic control islets. The modulation of pancreatic beta-cells may be involved in the experimental observation of anti-diabetic effects of M. charantia extract.”
“The chemical composition of essential oils obtained by hydrodistillation from the flower, leaf and stem of Falcaria vulgaris Bernh., which is endemic to Iran, were analysed by GC and GC/MS (samples were from Buparlisib molecular weight two different localities: A from Ardabil and B from Khalkhal). check details alpha-Pinene was the major constituent in all the three oils (flower, leaf and stem) from sample A(43.8%, 33.0% and 50.9%, respectively). The oil of F. vulgaris flower was characterised by a higher amount of beta-caryophyllene (25.2%) and 1,8-cineole (12.8%) among the eight components comprising 96.2% of the total oil detected. alpha-Terpinyl acetate (23.2%) and limonene (14.4%)
predominated in the leaf oil. In the oils of sample B, alpha-pinene (16.1% in the flower oil, 31.5% in the leaf oil and 34.5% in the stem oil) was the major compound. Limonene (14.2%) and germacrene D (32.1%) were also the main constituents found in the leaf oil from sample B. alpha-Terpinyl acetate (21.9% in the leaf oil) and limonene (29.8% in stem oil) were the other major compounds obtained from this sample. Antibacterial activity was determined by the measurement of growth inhibitory zones.”
“Swespine, the Swedish National Spine Register, has existed for 20 years and is in general use within the country since over 10 years regarding degenerative lumbar spine disorders. Today there are protocols for registering all disorders of the entire spinal column.
Patient-based pre- and postoperative questionnaires, completed before surgery and at 1, 2, 5 and 10 years postoperatively.