Pyramidal cells express mGluR7a in a uniquely high level in their terminals innervating O-LM cells, a signal that is unmistakable. Two bistratified cells (LK20p, LK27d) and one O-LM cell (LK06ah) were selected for reconstruction (see Supplemental Information). http://www.selleckchem.com/products/abt-199.html We thank K. Detzner, Sz. Biro, D. Kotzadimitriou, and Dr. J. Somogyi for advice and excellent technical support, Dr. B. Lasztoczi for help with analysis, and Dr. T. Szabadi and Sz. Biro for the reconstructions. One bistratified cell recoding was kindly provided by Dr. K. Hartwich. We thank Drs. Y. Dalezios and B. Hangya for advice on statistical analyses. We are grateful to Drs. Ray Guillery, D. Dupret, and B. Hangya for comments
on an earlier version of the manuscript. We thank L. Papp (Neuronelektrod, Budapest, Hungary) for designing and manufacturing miniature reference electrode drives. Z.B. was supported by grant SCIC03 of the Vienna Science and Technology Fund. “
“Marie T. Filbin,
Distinguished Professor of Biology at Hunter College in New York City, died on January 15, 2014 while visiting her family in Ireland. Following some early breakthrough work on the biochemistry of peripheral myelination, Marie’s most significant scientific contributions were in the JQ1 order understanding of the molecular mechanisms of the inhibition of axonal growth and the facilitation of axonal regeneration. Marie was a passionate and highly effective advocate for research PD184352 (CI-1040) in spinal cord injury and a tireless campaigner on behalf of patients with spinal cord disease, with some of whom she developed a deeply caring and life-long personal
relationship. Marie was the very antithesis of a “stuffy” scientist—she lived her life with flair and style, infectious charm, great (and occasionally irreverent) good humor, passion for her work, devotion to her friends and family, and was a remarkable mentor to her students. Marie T. Filbin: 1955–2014 Marie Therese Filbin was born in 1955 in the town of Lurgan, Northern Ireland, where her family had been in business for generations. She attended the University of Bath, where she received a PhD in Biochemistry in 1981 for work on the characterization of nicotinic acetylcholine receptors in the locust. In 1982, she moved to the University of Maryland for postdoctoral training without (she admitted) much detailed career planning but driven by a strong sense of adventure and discovery. The move to Baltimore proved fortuitous, however, when in 1984 she joined Gihan Tennekoon in the Department of Neurology at Johns Hopkins. In a seminal paper published with Dr. Tennekoon, Marie showed that that the tightly wound myelin leaflets that surround peripheral nerves are bound together by P0, the most abundant myelin protein, which functions as a hemophilic adhesion molecule (Filbin et al., 1990).