4:1), Zn (1.3:1), and Cu (1.3:1). Among the examined elements, only the level of MeHg in cord tissue was significantly (P < 0.001) higher (1.6 times) than that in placenta. However, Ceritinib in vitro the level of I-Hg level in placenta was significantly (P < 0.001) higher (2.4 times) than that in cord tissue. Consequently, the percentage of I-Hg vs. T-Hg in placenta (14.3%) was significantly (P < 0.001) and 3.3 times higher than

that in cord tissue (4.3%). The correlations between the placenta and cord tissue concentrations of MeHg, I-Hg, Pb, and Cd are depicted in Fig. 1. In all cases, the MeHg concentrations in cord tissue were higher than those in placenta, while the I-Hg and Cd concentrations in placenta were higher than those in cord tissues. In many cases, the Pb concentrations in placenta were higher than those of cord tissues. The correlations between the placenta and cord tissue concentrations of Se, Zn, and Cu are depicted in Fig. 2. FK228 supplier In all cases, the Se concentrations in placenta were higher than those in cord tissue. In many cases, the

Zn and Cu concentrations in placenta were higher than those in cord tissue. The medians and interquartile ranges of the T-Hg, Pb, Cd, Se, Zn, and Cu concentrations in maternal and cord RBCs are shown in Table 2. Among the toxic elements, only the T-Hg level in cord RBCs was significantly (P < 0.001) higher (1.5 times) than that in maternal RBCs. The Pb and Cd levels in cord RBCs were significantly (P < 0.001) lower than those in maternal RBCs. The Se, Zn, and Cu levels in cord RBCs were significantly (P < 0.001 for Se and Zn; P < 0.01 for Cu) higher than those in maternal RBCs. Table 3 shows the Spearman rank correlation coefficients of MeHg in placenta and cord tissue vs. T-Hg in maternal and cord RBCs. The MeHg in placenta showed significant (P < 0.001) correlations with T-Hg in maternal and cord RBCs (rs = 0.80 and 0.91, C1GALT1 respectively). The MeHg in cord tissue also

showed significant (P < 0.001) correlations with T-Hg in maternal and cord RBCs (rs = 0.75 and 0.85, respectively). Table 4 shows the Spearman rank correlation coefficients of T-Hg, Pb, Cd, Se, Zn, and Cu among placenta, cord tissue, maternal RBCs, and cord RBCs. The T-Hg in placenta showed significant (P < 0.001) and strong correlations with T-Hg in maternal and cord RBCs (rs = 0.81 and 0.90, respectively). The T-Hg in cord tissue showed significant (P < 0.001) and strong correlations with T-Hg in maternal and cord RBCs (rs = 0.74 and 0.85, respectively). In addition, the T-Hg showed significant (P < 0.001) and strong correlations among all the tissues examined. The Se in placenta showed significant but moderate correlations with the Se in maternal RBCs (rs = 0.38; P < 0.01) and cord RBCs (rs = 0.57; P < 0.001). The Se in cord tissue showed significant (P < 0.01) but moderate correlation with the Se in maternal RBCs (rs = 0.36).