, 2013). The total values have been reported in this study so that comparisons with other studies can be made. Overall it was possible to assign 95th percentile values for 45 of the elements measured in the urine samples (Table 3). The other 16 elements, Ag, Au Bi, Dy, Eu, In, Lu, Nb, Nd, Os, Pr, Sm, Tb, Tm, Y, and Zr all exhibited too high a percentage of results below the limit of detection. This is still useful information because it

is now known that these elements are low in urine samples from occupationally unexposed individuals and are not yet detectable with our existing methodologies. Comparing the data obtained from this studies from with Belgium (Hoet et al., 2013), France (Fréry selleck inhibitor et al., 2011) and US (NHANES, 2011) studies show that this study reports Fluorouracil 95th percentiles for 20 elements (B, Br, Ce, Er, Ga, Gd, Ge, Hf, Ho, Ir, La, Rb, Rh, Ru, Sc, Sr, Ta, Th, Ti and Yb) and < LOQ for 14 elements (Ag, Au, Dy, Eu, Lu, Nb, Nd, Os, Pr, Sm, Tb, Tm, Y and Zr) that have not been reported before in any of the other studies. The 95th percentiles established in this study were compared in Table 4 with those obtained from larger European and US based studies which were more comprehensive studies in terms of demographics, sample numbers and sample collection information. Data from a smaller UK based study

(White and Sabbioni, 1998) has also been used to compare this current UK data with. White and Sabbioni published their study in 1998 where urine Non-specific serine/threonine protein kinase samples from a similar UK population to this study were measured for thirteen elements as part of a larger EU study (White and Sabbioni, 1998). Comparing the results obtained in this study with those reported in 1998 showed that similar values were obtained for aluminium, molybdenum and nickel. However, slightly lower values were obtained for cobalt, copper, mercury, selenium and thallium and slightly higher values obtained for chromium in this study. In addition, this study showed considerably lower 95th percentile values for cadmium, lead and manganese from those reported in the White and Sabbioni study; with

urinary cadmium decreasing from 2.1 to 0.6 μmol/mol creatinine, urinary lead decreasing from 27.2 to 4.1 μmol/mol creatinine and urinary manganese decreasing from 3.1 to 1.3 μmol/mol creatinine. In the UK leaded petrol was removed from sale by the year 2000 and so it is likely that the decrease in urinary lead levels are as a direct result of this as evidenced by a similar reduction in the lead although at lower concentrations in the US NHANES study, where the levels decreased from 1.26 to 0.86 μmol/mol creatinine from 1999–2000 to 2009–2010 (NHANES, 2011). In comparing the data in Table 4 the 95th percentiles obtained for antimony (Hoet et al., 2013, Fréry et al., 2011 and NHANES, 2011), barium (Hoet et al.