A large trial validated the equivalency of fosaprepitant, a single-day intravenous formulation, with aprepitant; either therapy is appropriate. Preferential

use of palonosetron is recommended for moderate emetic risk regimens, combined with dexamethasone. For low-risk agents, patients can be offered dexamethasone before the first dose of chemotherapy. Patients undergoing high SNS-032 emetic risk radiation therapy should receive a 5-HT3 receptor antagonist before each fraction and for 24 hours after treatment and may receive a 5-day course of dexamethasone during fractions 1 to 5. The Update Committee noted the importance of continued symptom monitoring throughout therapy. Clinicians underestimate the incidence of nausea, which is not as well controlled as emesis. J Clin Oncol 29:4189-4198. (C) 2011 by American Society of Clinical Oncology”
“In order to reveal the chemical characteristics of Glycyrrhiza uralensis growing in Mongolia and to clarify whether it can be the source of Glycyrrhizae Radix used in Japan, eight major bioactive constituents in the underground parts of G. uralensis collected in Mongolia were quantitatively analyzed and

compared with Glycyrrhizae Radix produced in China. Most of the 15 samples from eastern, southern and western parts of Mongolia contained 26.95-58.55 mg/g of glycyrrhizin, exceeding the criterion (25 mg/g) assigned in the Japanese Pharmacopoeia. The sample collected in Tamsagiyn hooly, Dornod province, in eastern Mongolia was of the highest content 58.55 mg/g. The contents of three flavanone constituents see more (liquiritin

apioside, check details liquiritin and liquiritigenin) and three chalcones (isoliquiritin apioside, isoliquiritin and isoliquiritigenin) varied significantly according to collection places; the subtotal of the three flavanones ranged from 3.00 to 26.35 mg/g, and the subtotal of the three chalcones ranged from 1.13 to 10.50 mg/g. The content of glycyrrhizin and subtotal contents of flavanones and chalcones in the underground parts of G. uralensis from Mongolia were obviously lower than wild samples, but higher than cultivated samples derived from the same species produced in China. Glycycoumarin, a species-specific constituent of G. uralensis, was detected in all Mongolian samples. Its contents in samples from eastern Mongolia, Sergelen and Tamsagiyn hooly of Dornod province were very high and were compatible with Tohoku-kanzo derived from wild Chinese G. uralensis. The present study suggested that Mongolian G. uralensis could be a source of Glycyrrhizae Radix, mostly of Japanese Pharmacopoeia grade. However, the producing area should be taken into consideration to ensure relatively high quality. In addition, planned use and promotion of cultivation must be advocated to avoid confronting Mongolian Glycyrrhiza with the same threat as its congener in China.

\n\nResults Three hundred and fifty-eight patients underwent genetic testing (HHT, n = 332; JP, n = 26). Among fourteen patients identified with SMAD4 mutations, ten met the clinical diagnostic criteria for both JP and HHT (71%). Patients with SMAD4 mutations had 100% penetrance of the polyposis phenotype. All patients with JP and SMAD4 mutation had features of HHT. Three JP-HHT patients developed early onset colorectal cancer (CRC) (mean age 28 years). JP-HHT patients with SMAD4 mutation had a significantly higher rate of anemia than HHT patients with mutations other than SMAD4.\n\nConclusions Patients with HHT and SMAD4 mutations are at significant risk of JP and CRC. The gastrointestinal phenotype is similar to JP patients

without

SMAD4 mutation. It is essential for HHT patients to undergo genetic testing to determine if they have SMAD4 mutations so that appropriate gastrointestinal Selleckchem Autophagy Compound Library screening and surveillance for JP and CRC can be completed.”
“Background: Metabolic syndrome (MS) is a cluster AC220 of the most dangerous cardiac risk factors and is associated with high mortality. Ethnic differences in metabolic syndrome (MS) criteria and prevalence rates have been reported. The purpose of this study was to investigate the MS prevalence among patients with schizophrenia in Palestine.\n\nMethods: We recruited 250 patients with schizophrenia from 4 psychiatric primary healthcare centers in Northern Palestine. The MS prevalence was assessed based on National Cholesterol Education Program Adult Treatment Panel III Adapted criteria.\n\nResults: The overall MS prevalence was 43.6%, with 39% in male and 55.9% in female patients. On average, the study patients had 2.3 +/- 1.3 metabolic abnormalities. Univariate analysis showed that MS was significantly higher with older age, female gender, longer duration of the illness, smoking, abdominal obesity, high systolic and diastolic blood pressure, high triglycerides, low MGCD0103 HDL-C, and high fasting plasma glucose. Multiple logistic regression analysis showed that only systolic blood pressure, high triglycerides, high fasting plasma

glucose, and low HDL-C were significant predictors of MS in schizophrenic patients.\n\nConclusions: MS is common among Arab patients with schizophrenia. Patients with schizophrenia should receive regular monitoring and adequate treatment of cardio-metabolic risk factors.”
“Purpose To identify prognostic factors affecting visual outcome in Acanthamoeba keratitis (AK) treated with topical chlorhexidine gluconate (CHG).\n\nMethods A total of 35 eyes in 34 patients with AK were treated with 0.02% topical CHG. Patients were divided into two groups according to the final visual outcome: Group 1, final visual acuity (VA) of 20/25 or greater (22 eyes); Group 2, less than 20/25 (13 eyes). We compared these groups and evaluated the effectiveness of topical CHG compared with outcomes in previous reports.\n\nResults Ring infiltrate was observed more often in Group 2 (4.

For an patients, standardized anesthesia AZD1390 inhibitor was used. Prediction probabilities of BIS and cAAI versus the University of Michigan Sedation Scale and sensitivity/specificity were calculated.\n\nResults: Prediction probabilities for BIS and cAAI during induction were 0.84 for both and during emergence were 0.75 and 0.74, respectively. At loss of consciousness, the median BIS remained unaltered (94 to 90; not significant), whereas cAAI values decreased (60 to 43; P < 0.001). During emergence, median BIS and cAAI increased from 51 to 74 (P < 0.003) and from 46 to 58 (P < 0.001), respectively. With respect to indicate consciousness or unconsciousness,

100% sensitivity was reached at cutoff values of 17 for HIS and 12 for cAAI. One hundred percent specificity was associated with a BIS of 71 and a cAAI of 60. To ascertain consciousness, BIS Epigenetic inhibitor supplier values greater than 78 and cAAI values above 52 were required.\n\nConclusions: BIS and cAAI were comparable indicators of depth of hypnosis in children. Both indices, however, showed considerable overlap for different clinical conditions.”
“26S proteasomes consist

of cylindrical 20S proteasomes with 19S regulatory complexes attached to the ends. Treatment with high concentrations of salt causes the regulatory complexes to separate into two sub-complexes, the base, which is in contact with the 20S proteasome, and the lid, which is the distal part of the 19S complex. Here, we describe two assembly intermediates of the human regulatory complex. One is a dimer of the two ATPase subunits, Rpt3 selleck screening library and Rpt6. The other is a complex of nascent Rpn2, Rpn10, Rpn11, Rpn13, and Txnl1, attached to preexisting 20S proteasomes. This early assembly complex does not yet contain Rpn1 or any of the ATPase subunits of the base. Thus, assembly of 19S regulatory complexes takes place on preexisting 20S proteasomes, and part of the lid is assembled before the base. (C) 2009 Elsevier Ltd. All rights reserved.”
“To study the effect of DM1-associated CTG repeats on neuronal function, we developed a PC12 cell-based model that constitutively expresses the DMPK gene 3′-untranslated region with 90 CTG repeats (CTG90 cells). As CTG90 cells

exhibit impaired neurite outgrowth and as microtubule-associated proteins (MAPs) are crucial for microtubule stability, we analyzed whether MAPs are a target of CTG repeats. NGF induces mRNA expression of Map2, Map1a and Map6 in control cells (PC12 cells transfected with the empty vector), but this induction is abolished for Map2 and Map1a in CTG90 cells. MAP2 and MAP6/STOP proteins decrease in NGF-treated CTG90 cells, whereas MAP1A increases. Data suggest that CTG repeats might alter somehow the expression of MAPs, which appears to be related with CTG90 cell-deficient neurite outgrowth. Decreased MAP2 levels found in the hippocampus of a DM1 mouse model indicates that targeting of MAPs expression by CTG repeats might be relevant to DM1.

Respiratory functions, blood gases, functional capacity (peak oxygen consumption (pVO2), shuttle walk test (SWT), endurance shuttle walk test (ESWT), dyspnea [Medical Research Council (MRC) Dyspnea Scale], quality of life (Saint George’s Respiratory Questionnaire, SGRQ), and psychological symptoms (Hospital Anxiety and Depression Scale, HADS) tests before and after an 8-week rehabilitation program were obtained from patients’ medical records.\n\nResults: After selleck chemical the rehabilitation program, a significant improvement

in pVO2, ESWT, SGRQ (symptom, activity, impact subscale and the total score), and MRC dyspnea scale (p<0.05) was observed in both groups, compared to the pre-rehabilitation period. In contrast, no significant improvement was observed in either groups following the rehabilitation program with respect to respiratory function tests (ZEV1 (ml,%), ZVK (ml, %), ZEV1/ZVK (%), blood gas measurements (paO2, paCO2, oxygen saturation), SWT, and HADS (p>0.05). On the other hand, see more in inter-group comparison,

the significant low values of ZEV1 and ZEV1/ZVK in the pre-rehabilitation period in Group 1 compared to Group 2, also persisted after rehabilitation (p<0.05). The comparisons regarding the rest of parameters did not reveal any significant difference (p>0.05).\n\nConclusion: Outpatient pulmonary rehabilitation improves functional capacity, dyspnea, and quality of life in patients with COPD and non-CORD. Whatever the dyspnea etiology was, a regular exercise program in the rehabilitation unit is recommended for patients with chronic pulmonary diseases. Turk J Phys Med Rehab 2010;56:6-10. Key

Selleck GPCR Compound Library Words: Pulmonary rehabilitation, quality of life, functional capacity, dyspnea, psychological symptoms”
“Actor-Network Theory is a controversial social theory. In no respect is this more so than the role it gives’ to nonhumans: nonhumans have agency, as Latour provocatively puts it. This article aims to interrogate the multiple layers of this declaration to understand what it means to assert with Actor-Network Theory that nonhumans exercise agency. The article surveys a wide corpus of statements by the position’s leading figures and emphasizes the wider methodological framework in which these statements are embedded. With this work done, readers will then be better placed to reject or accept the Actor-Network position – understanding more precisely what exactly it is at stake in this decision.”
“Muscle and bone form a functional unit. While muscle size is a useful surrogate of mechanical load on bone, the independent contributions to bone strength of muscle force, muscle size, gravitational load (body weight), and physical activity have not been assessed. Three hundred twenty-one healthy participants (32% black, 47% male), aged 5-35 years were assessed.

First-year students at 16 Norwegian Elite Sport High Schools (n=677) and two randomly selected high schools

(controls, n=421) were invited to participate. Totally, 602 athletes (89%) and 354 (84%) controls completed the questionnaire. More controls than athletes were smoking, using snus, and drinking alcohol. Competing in team sports was associated with use of snus [odds ratio=2.8, 95% confidence interval (CI) 1.6 to 4.7] and a similar percentage of male and female handball (22.2% vs 18.8%) and soccer players (15.7% vs 15.0%) reported using snus. For controls, not participating in organized sport was a predictor for smoking (odds ratio=4.9, 95% CI 2.2 to 10.9). Female athletes were more prone to drink alcohol than males (46.3% vs 31.0%, P<0.001). Only, 1.2% athletes and 2.8% controls reported use of performance-enhancing illicit drugs. In conclusion, use of legal drugs is less common HM781-36B among athletes, but this relationship depends on type of sport and competition level. The association between team sports and use of snus suggests that sport subcultures play a role.”
“Nitrogen (N) deposition is a major threat to biodiversity of many habitats in the lowlands. In mountain habitats, however, the effect of N deposition on biodiversity is not well understood. Here, data from the biodiversity

monitoring of Switzerland were used to investigate whether high N deposition is negatively related to species GSK1838705A Protein Tyrosine Kinase inhibitor richness Combretastatin A4 manufacturer and community uniqueness of vascular plants and bryophytes in mountain grassland. The total species diversity, as well as the diversity of three subsets of species (i.e. oligotrophic species, eutrophic species and targeted grassland species

according to conservation objectives of the Swiss authorities) were analyzed. Overall, the empirical data from the present study indicate that the currently expert-based range of the critical load of N deposition below which harmful effects on sensitive ecosystems should not occur (upper bound is currently at 20 kg N ha(-1) yr(-1)) is set too large for mountain hay meadows. Negative relations between N deposition and species richness and community uniqueness in mountain grassland were found already at 10-15 kg N ha(-1) yr(-1). The results suggest that the negative effect of N deposition on plant diversity is mainly due to a decrease of oligotrophic plant species and to a lesser extent to an increase in eutrophic plant species. While for bryophytes, the decrease of community uniqueness is related to changes in both oligotrophic and eutrophic species. Furthermore, because plant species richness of target.species for conservation was negatively related to N deposition, airborne N deposition is likely to defeat conservation efforts in mountain grassland. (C) 2013 Elsevier B.V. All rights reserved.

We tested six healthy control subjects with visual acuity of at least 20/20. The tests were performed on each subject three times on different days. We found significant temporal differences between the CRT and the LCD monitors at all contrast levels and spatial frequencies. In average, the latency times were 9.0 ms (+/- 3.3 ms) longer with the TFT stimulator. This value is in accordance with the average of the measured TFT input-output temporal difference values (10.1 +/- A 2.2 ms). According to our findings, measuring the temporal Liproxstatin-1 mouse parameters of the TFT monitor with an adequately calibrated

measurement setup and correcting the VEP data with the resulting selleck chemicals values, the VEP signals obtained with different display types can be transformed to be comparable.”
“The recent Mental Capacity Act (2005) sets out a test for assessing a person’s capacity to make treatment choices. In some cases, particularly in psychiatry, it is unclear how the criteria ought to be interpreted and applied by clinicians. In this paper, I argue that this uncertainty

arises because the concept of capacity employed in the Act, and the diagnostic tools developed to assist its assessment, overlook the inherent normativity of judgements made about whether a person is using or weighing information in the decision-making process. Patients BX-795 may fail on this criterion to the extent that they do not appear to be handling the information given in an appropriate way, on account of a mental impairment disrupting the way the decision process ought to proceed. Using case law and clinical examples, I describe some of the normative dimensions along which judgements of incapacity can be made, namely epistemic, evaluative and affective dimensions. Such judgements are complex and the normative standards by which a clinician may determine capacity cannot be reduced to a set of criteria. Rather, in recognizing this normativity, clinicians may better understand how clinical judgements are structured and what kinds of assumption may inform their assessment.”
“P>Interactions

between vascular plants and bryophytes determine plant community composition in many ecosystems. Yet, little is known about the importance of interspecific differences between bryophytes with respect to their effects on vascular plants. We compared the extent to which species-specific bryophyte effects on vascular plant generative recruitment depend on the following underlying mechanisms: allelopathy, mechanical obstruction, soil moisture and temperature control.\n\nWe sowed 10 vascular plant species into monospecific mats of six chemically and structurally diverse bryophytes, and examined 1-yr seedling recruitment. Allelopathic effects were also assessed in a laboratory phyto-assay.

This study is the first to demonstrate that subchronic lithium treatment decreases Gln and Glx levels in the bilateral basal ganglia of healthy individuals. Our finding might suggest that the decrease of Glx levels is associated with the pharmacological actions of subchronic lithium treatment. (c) 2007 Elsevier Inc. All rights reserved.”
“The detection of small amounts of free peritoneal gas in the canine patient can pose a diagnostic dilemma. The objective of this study was to determine how much of this free gas could be detected ultrasonographically. Ultrasound examinations

were carried out after increments (0.1 ml) of air were intraperitoneally injected. learn more Via ultrasonography, 0.4 ml of free gas can be reliably detected. The authors concluded that ultrasonography is a very sensitive modality for the detection of small amounts of peritoneal free gas (above 0.4 ml).”
“To date, different water-quality indices (WQIs) categorizing water bodies have flourished in the literature. While this website this type of index has normally been applied to data sets from manual monitoring programs, we focus attention on the analysis of data from automated sampling networks, from which measurements of a small number of physico-chemical variables are usually obtained from different locations with

high temporal resolution.\n\nTo deal with data of this nature, we compare different indices for the physico-chemical evaluation of water quality. As a result, we select the WQI of the Canadian Council of Ministers of the Environment (CCME WQI) as the most suitable. Our interest in using this WQI rests on its flexibility for selecting parameters as well as the possibility of modifying the objectives to be met by each variable according to the specific end use of the water.\n\nWe perform a sensitivity analysis for the CCME WQI in order to select the best procedure for calculating it according to SNX-5422 in vitro input data. Finally, we apply the CCME WQI to simulated data sets describing three different environmental scenarios corresponding to episodes of discharge of urban wastewater, eutrophication and risk to

fish. From this comparison and according to the specific objectives we define in this work, we rank sensitivity in CCME WQI performance in the following order: (1) urban wastewater; (2) eutrophication; and, finally, (3) risk to fish. (C) 2009 Elsevier Ltd. All rights reserved.”
“Objectives. Previous studies have suggested that gastrointestinal integrity is compromised after cardiopulmonary bypass (CPB). We compared the effects of prolonged minimized (MCPB) and conventional CPB (CCPB) on intestinal mucosal integrity by determining mucosal damage, epithelial cell proliferation rate and distribution of tight junction proteins in a porcine model. Design. Fourteen animals were randomly assigned to undergo 240 minutes of mild hypothermic MCPB or CCPB.

The association of SNPs with tumor recurrence and overall survival was then analyzed by additive, dominant, recessive, and click here overdominant models in a cohort of 156 HCC

patients. Results: In terms of tumor recurrence, heterozygous of SNP rs1990172 and SNP rs975263 showed a significant high risk of relapse using univariate and multivariate analysis (overdominant, HR(95%CI)=2.27 [1.41-3.66], P=0.001; HR(95%CI)=2.16 [1.37-3.39], P=0.001). But the difference between heterozygous of these two SNPs and overall survival did not reach a significance in all models. The other three investigated SNPs were not significantly associated with tumor recurrence and overall survival (P>0.05). In addition, we found no significant difference in genotype frequencies between HCC and controls. Conclusions: Our data suggest that SNP rs1990172 and SNP rs975263 in the MACC1 gene may be potential genetic markers for Transmembrane Transporters inhibitor HCC recurrence in LT patients.”
“Purpose: The purpose of the study was to prospectively compare operative and postoperative characteristics and outcomes in elderly patients undergoing percutaneous nephrolithotomy (PCNL) compared with younger patients.\n\nPatients and Methods: Prospectively collected data from the Clinical Research Office of the Endourological Society (CROES) Global PCNL Study database

were used. Elderly patients were defined as those aged 70 years and above, while younger patients were those between 18 and 70 years of age. Matched and unmatched group comparisons were performed based on imaging modality used for assessing stone-free status. Patient characteristics, operative data, and postoperative outcomes were compared.\n\nResults: The median age of the elderly group vs the young selleck kinase inhibitor group was 74 years (range 70-93 years) vs 49 years. In the unmatched analysis, staghorn stones were seen at higher rates in the elderly group (27.8% vs 21.8%, P = 0.014); however, the mean stone size was not significantly different (465.0 vs 422.8, P =

0.063). The length of hospitalization was significantly longer in the elderly group compared with the young group in the unmatched analysis (5 days vs 4.1 days, P < 0.001). The same difference was not apparent in the matched analysis (5.0 days vs 4.4 days, P = 0.288). Overall complication rates were not significantly different in the unmatched analysis. In the matched analysis, however, a statistically significant higher rate of overall complications was seen. Stone-free rates were similar among all groups.\n\nConclusion: PCNL in elderly patients over the age of 70 years produces results comparable to those seen in younger patients. With only a slightly higher-be it statistically significant-complication rate, the stone-free rate in older patients was the same as in the younger group.

(C) 2010 Elsevier Ltd. All rights reserved.”
“Aims: Cancer development and progression is not only associated with the tumor cell proliferation but also depends on the interaction between tumor cells and the stromal microenvironment. A new understanding of the role of the tumor microenvironment suggests that the loss of stromal caveolin-1 (Cav-1) as a key regulator may become Cilengitide datasheet a potential therapy target. This study aims to

elucidate whether stromal Cav-1 expression in pancreatic cancer can be a strong prognosis biomarker. Methods: Tissue samples from 45 pancreatic cancer patients were studied. Parenchyma and stroma were separated and purified using laser capture microdissection. Stromal Cav-1 expression was measured from pancreatic cancer, paraneoplastic, and normal tissue using immunohistochemistry. We analyzed the correlation selleckchem of stromal Cav-1 expression with clinicopathologic features and prognostic indicators, such as tumor marker HER-2/neu gene. Results: Specimens from six patients (13.3%) showed high levels of stromal Cav-1 staining, those from eight patients (17.8%) showed a lower, intermediate

level of staining, whereas those from 31 patients (68.9%) showed an absence of staining. Cav-1 expression in cancer-associated fibroblasts was lower than that in paracancer-associated and in normal fibroblasts. Stromal Cav-1 loss was associated with TNM stage (P=0.018), lymph node metastasis (P = 0.014),

distant metastasis (P = 0.027), and HER-2/neu amplification (P = 0.007). The relationships of age, sex, histological grade, and tumor size with stromal Cav-1 expression were not significant (P bigger than 0.05). A negative correlation was found between circulating tumor cells and stromal Cav-1 expression (P smaller than 0.05). Conclusion: The loss of stromal Cav-1 in pancreatic cancer was an independent prognostic indicator, thus suggesting that stromal Cav-1 may be an effective therapeutic target for patients with pancreatic cancer.”
“Inadequate pharmacological treatment has been identified as a serious problem in the treatment of congestive heart failure. We analysed the adjustments of medication in a mobile app-based closed loop healthcare monitoring programme and investigated whether mHealth-based monitoring supports dynamic medication Selleck ALK inhibitor management. Our results indicate that adjustments of medication management are common. Not only do physicians often change doses and types of drugs but also patients frequently change the medication dosage based on their individual experience.”
“The copper-catalyzed azide-alkyne cycloaddition click reaction is a valuable process for the synthesis of libraries of drug candidates, derivatized polymers and materials, and a wide variety of other functional molecules. In some circumstances, the removal of the copper catalyst is both necessary and inconvenient.

Sixty Wistar female rats used were divided into four groups: (1) normal rats (control), (2) diabetic rats, (3) diabetic rats treated with VACC, and (4) diabetic Crenigacestat in vitro rats treated with vanadium nitrate. A standardized type 1-like diabetes model was induced by injection of streptozotocin.

After the rats were treated orally with VACC and IV respectively, plasma glucose, body weights, micro-CT, biomechanical testing, and histomorphometry were examined. In addition, bone samples were obtained to evaluate the content of mineral substances in bones. Treatments were performed over a 12-week period. Both VACC and IV have a positive effect on plasma glucose and body weights of STZ-induced diabetic rats. However, treatment with IV only caused a 39.6 % decrease in glucose levels and a 14.6 % increase in body weights, whereas VACC decreased plasma glucose and increased body weights by up to 52.2 and 24.5 %, respectively. At the same time, VACC significantly improved trabecular microstructure and mechanical strength, while IV did not exhibit desirable such effects. Also, bone Ca and bone P were not significantly increased by IV. These results indicated that both VACC and IV have hypoglycemic activity on diabetic rats, while IV did not improve bone properties. In conclusion, this study suggests that VACC improves diabetes-related bone

dysfunction, primarily by improving Adavosertib clinical trial the diabetic states.”
“CXCL8 and its receptors (CXCR1 and CXCR2) play important roles in CNS development, neuronal survival, modulation of excitability, and neuroimmune response. The aim of this study is to evaluate gene expression of CXCL8 and CXCR1/CXCR2 in peripheral blood cells (PBCs) of Iranian patients with relapsing remitting (RR) form of Multiple sclerosis LY3039478 clinical trial (MS). We explored the mRNA expression of CXCL8 and its receptors in PBCs of 49 RR-MS patients in remitting status and 60 healthy controls by quantitative Real-Time PCR. Median expression of CXCL8 mRNA in peripheral blood of MS patients decreased more than 3-fold compared to control group

(p<0.001), while there were not significant differences in CXCR1 and CXCR2 gene expression between MS patients and healthy subjects (p = 0.159 and p = 0.248, respectively). There was a significant negative correlation of CXCR2 expression with EDSS (rs = -0.432, p = 0.004). It appears that decreased expression of CXCL8 may lead to a raised risk of MS.”
“BACKGROUND. Metastases to the brain front ovarian and endometrial carcinoma are uncommon and to the authors’ knowledge consensus regarding optimal management is lacking. Stereotactic radiosurgery (SRS) has proven Useful for the treatment of many benign and malignant brain tumors.. In the current study, the authors evaluated outcomes after SRS in patients with ovarian and endometrial carcinoma.\n\nMETHODS. Twenty-seven patients with brain metastases Underwent gamma-knife SRS.