29 In the study, it

was observed that patients reactive to Bombyx mori at the SPT showed a higher frequency of positivity and higher levels of serum specific IgEs for Blattella germanica, which could be explained by the cross‐reactivity between them. However, the same did not occur when comparing the positive skin reactions between moth and cockroach, but the immunochemical analysis of these allergens was not performed. Moreover, inhibition tests with extracts from moth and mites showed differences between their antibodies, demonstrating that there is no cross‐reactivity between them.12 In the study, there was no association between the frequency of skin reactivity at the SPT to mite and moth antigens (Dermatophagoides pteronyssinus and Blomia tropicalis).

Similarly, there was no association between positivity at the SPT for Bombyx mori and the presence of specific serum IgE to mites Panobinostat in vivo (Dermatophagoides pteronyssinus, Dermatophagoides farinae, and Blomia see more tropicalis), probably because there is no cross‐reactivity between them. One study from China identified another allergen component of Bombyx mori (Bom m 7), also obtained from the larvae of this insect, but consisting of tropomyosin protein.30 It is considered a pan‐allergen, able to show broad cross‐reactivity with components of other insects such as Der p 10 (from the Dermatophagoides pteronyssinus mite) and Bla g 7 (from the Blattella germanica cockroach).31 and 32 Therefore, to verify true allergic sensitization or cross‐reactivity, future studies should be performed, based on molecular allergy diagnosis, but using allergenic components of the Bombyx mori moth and not of its larvae as a cause of respiratory allergic symptoms.33 and 34 This study was the first on sensitization to the silkworm moth performed in Brazil, and showed the importance of Bombyx mori as a sensitizing allergen in children and adolescents diagnosed with allergic respiratory

diseases (asthma and/or rhinitis). A high frequency of sensitization to Bombyx mori was found in patients evaluated why by SPT with an extract prepared from the wings of moths; these results were confirmed by ImmunoCAP®, a well‐established method for detection of specific serum IgE. The identification of this aeroallergen (moth), together with the other groups that compose the profile of allergic sensitization in this population, should make their treatment more efficient, as it will allow for adjustments in environmental control procedures, as well as provide new specific immunotherapy options in the future. The authors declare no conflicts of interest. “
“Neonatal mortality has been defined as mortality occurring during the first 28 days of life. It is mostly associated to infections that are either congenital or acquired after birth. These infections strongly impact the causes of death and abortion in non-industrialized countries.