77 100 177 0.90 100 23 0.64 Cohort entry 2000–2004 78 166 0.78 73 113 0.86 0 Cohort entry 2005–2006 22 59 0.74 27 64 0.97 100 23 0.64 Age 65–74 years 49 38 0.26 47 33 0.35 53 5 0.26 Age 75 and over 51 187 1.26 53 144 1.38 47 18 1.07 Glucocorticoid use 5 20 1.26 6 18 1.55 6 1 – No glucocorticoid use 95 205 0.74 94 159 0.86 94 22 0.65 Hormone therapy use 14 23 0.55 12 9 0.37 9 1 – No hormone use 86 202 0.81 88 168 0.97 91 22 0.68 Prior clinical fracturea 9 49 1.86 9 32 1.85 7 1 – No fracture 91 176 0.66 91 145 0.81 93
22 0.66 Prior bisphosphonate useb 7 19 0.90 13 28 1.09 40 10 0.71 No prior use 93 206 0.76 87 149 0.87 60 13 0.60 p-y person-years. The calculation of rate is based on the number of fractures divided person-years of observation during www.selleckchem.com/products/AG-014699.html first 3 months after starting therapy. No rates reported for three or less fractures aIn the 6 months before cohort entry, any clinical fracture diagnosis at the hip, clavicle, wrist, humerus, leg, pelvis, or vertebral sites bIn the 4 years before cohort entry, use of any bisphosphonate regardless of duration of administrative billing data before cohort entry. Change in fracture incidence over time After the
initial 3-month period, the incidence of fractures was observed in the subsequent Decitabine purchase 1 year while on therapy. Relative to the baseline incidence of the initial 3-month
period, the incidence of clinical fractures at the hip, vertebral, and nonvertebral sites was significantly lower in the subsequent 12 months in both cohorts of alendronate and risedronate (Table 3). The incidence of vertebral fractures in the subsequent 1 year was lower in the ibandronate cohort. Table 3 Incidence of clinical fractures in the 3 months after starting therapy and subsequent 1 year on therapy Cohort (cohort Palbociclib in vivo size) Fracture site Baseline Follow-up Ratio (95% CI) of fracture incidence for follow-up/baseline Three-month period after starting therapy Subsequent 1-year period on therapy Number of subjects with fracture Person-years of observation Fracture incidence per 100 person-years Number of subjects with fracture Person-years of observation Fracture incidence per 100 person-years Alendronate (n = 116,996) Nonvertebral 1,026 29,249 3.51 1,524 60,108 2.52 0.72 (0.67–0.78) Hip 225 29,249 0.77 378 60,108 0.63 0.82 (0.69–0.96) Vertebral 736 29,249 2.52 647 60,108 1.08 0.43 (0.38–0.48) Risedronate (n = 78,860) Nonvertebral 669 19,715 3.39 1,021 38,140 2.68 0.79 (0.72–0.87) Hip 177 19,715 0.90 250 38,140 0.66 0.73 (0.60–0.89) Vertebral 499 19,715 2.53 442 38,140 1.16 0.46 (0.40–0.52) Ibandronate (n = 14,288) Nonvertebral 113 3,572 3.16 212 7,274 2.91 0.92 (0.73–1.