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“BACKGROUND: The demand for enantiomerically pure molecules is growing continuously and biocatalysis is a powerful technique for their

production. In this work, the catalyst was an enzyme combined with its coenzyme, NADP. High pressure technology, a second clean technology, was applied as well. Dense gases are promising solvents for biocatalysis. They have been investigated extensively as reaction media for lipase-catalysed reactions, but seldom for reactions, catalysed with alcohol dehydrogenases, as in this work.

RESULT: The production of optically Dorsomorphin order pure R-1-phenylethanol from acetophenone was investigated. The NADP-dependent alcohol dehydrogenase from Lactobacillus brevis (LBADH) was used as a catalyst. The hydrogenation was performed with isopropanol as

a co-substrate in different conditions: dense propane with LBADH and NADP co-immobilized on glass beads and in the biphasic system water/dense propane. The obtained R-1-phenylethanol was enantiopure. The conversions were up to 90%. Deactivation Screening Library purchase of LBADH was also measured in these media.

CONCLUSION: Protocols were successfully developed for the testing of alcohol dehydrogenase activity in dense gases. Enantioselectivity of LBADH is excellent in those media but it deactivated quickly. An LBADH-catalysed reaction was performed in a dense gas for the first time. (C) 2010 Society of Chemical Industry”
“Objective: This clinical trial aimed to evaluate the clinical results of the use of a tulip fibre versus the use of a bare fibre for endovenous laser ablation.

Methods: In a multicentre prospective randomised trial 174 patients were randomised for the treatment of great saphenous vein reflux. A duplex scan was scheduled 1 month, 6 months and 1 year postoperatively. Ecchymosis was measured on the 5th postoperative day. In addition, pain, analgesics requirement, postoperative quality of life (CIVIQ 2) and patient satisfaction rate were noted.

Results: Patients treated

with a tulip fibre had significantly less postoperative ecchymosis (0.04 vs. 0.21; p < 0.001) and pain (5th day) (1.00 vs. 2.00; p < 0.001) and had a better postoperative quality of life MG-132 purchase (27 vs. 32; p = 0.023). There was no difference in analgesic intake (p = 0.11) and patient satisfaction rate (p = 0.564). The total occlusion rate at 1 year was 97.02% and there was no significant difference between the two groups (p = 0309).

Conclusion: Using a tulip fibre for EVLA of the great saphenous vein results, when compared with the use of a bare fibre, in equal occlusion rates at 1 year but causes less postoperative ecchymosis and pain and in a better postoperative quality of life. (C) 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.”
“Liquid-phase mixing is a common operation, often performed in vessels using mechanically rotating impellers.