Biochem Soc Trans 2004, 32 (Pt 5) : 742–745.PubMed 17. Ichinose J, Murata M, Yanagida T, Sako Y: EGF signalling amplification induced by dynamic clustering of EGFR. Biochem Biophys Res Commun 2004, 324 (3) : 1143–1149.CrossRefPubMed 18. Bray D, Levin MD, Morton-Firth CJ: Receptor clustering as a cellular mechanism

to control sensitivity. Nature 1998, 393 (6680) : 85–88.CrossRefPubMed 19. Crouch MF, Davy DA, Willard FS, Berven LA: Insulin induces epidermal growth factor (EGF) receptor clustering and potentiates EGF-stimulated KU55933 supplier DNA synthesis in swiss 3T3 cells: a mechanism for costimulation in mitogenic synergy. Immunol Cell Biol 2000, 78 (4) : 408–414.CrossRefPubMed 20. Gilcrease MZ, Zhou X, Welch K: Adhesion-independent alpha6beta4 integrin clustering is mediated by phosphatidylinositol 3-kinase. Cancer Res 2004, 64 (20) : 7395–7398.CrossRefPubMed 21. Hogervorst Regorafenib F, Selleck BI 10773 Kuikman I, van Kessel AG, Sonnenberg A: Molecular cloning of the human

alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes. Eur J Biochem 1991, 199 (2) : 425–433.CrossRefPubMed 22. Dowling J, Yu QC, Fuchs E: Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol 1996, 134 (2) : 559–572.CrossRefPubMed 23. Nagato T, Yoshida H, Yoshida A, Uehara Y: A scanning electron microscope study of myoepithelial cells in exocrine glands. Cell Tissue Res 1980, 209 (1) : 1–10.CrossRefPubMed 24. Shaw LM, Rabinovitz I, Wang HH, Toker A, Mercurio AM: Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell 1997, 91 (7) : 949–960.CrossRefPubMed 25. O’Connor KL, Nguyen BK, Mercurio AM: RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism. J Cell Biol 2000, 148 (2) : 253–258.CrossRefPubMed 26. Rabinovitz I, Mercurio AM: The integrin alpha6beta4

functions in carcinoma cell migration on laminin-1 by mediating L-NAME HCl the formation and stabilization of actin-containing motility structures. J Cell Biol 1997, 139 (7) : 1873–1884.CrossRefPubMed 27. Rabinovitz I, Gipson IK, Mercurio AM: Traction forces mediated by alpha6beta4 integrin: implications for basement membrane organization and tumor invasion. Mol Biol Cell 2001, 12 (12) : 4030–4043.PubMed 28. O’Connor KL, Shaw LM, Mercurio AM: Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells. J Cell Biol 1998, 143 (6) : 1749–1760.CrossRefPubMed 29. Mainiero F, Murgia C, Wary KK, Curatola AM, Pepe A, Blumemberg M, Westwick JK, Der CJ, Giancotti FG: The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. Embo J 1997, 16 (9) : 2365–2375.CrossRefPubMed 30.