\n\nConclusions: Paphiopedilum species display many chromosomal rearrangements – for example, duplications, translocations, and inversions – but only weak concerted evolutionary forces

among highly duplicated 5S arrays, which suggests that double-strand break repair processes are dynamic and ongoing. These results make the genus a model system for the study of complex chromosomal evolution in plants.”
“Aim\n\nTotal mesorectal excision (TME) is currently the gold standard for resection of mid or low rectal cancer and is associated with a low local recurrence rate. However, few studies have reported the long-term oncological outcome following use of a laparoscopic approach. The aim of this study was to evaluate the long-term oncological outcome after laparoscopic sphincter-preserving TME with a median follow up of about 4

years.\n\nMethod\n\nPatients KPT-8602 with mid or low rectal cancer who underwent laparoscopic MK5108 sphincter-preserving TME with curative intent between March 1999 and March 2009 were prospectively recruited for analysis.\n\nResults\n\nDuring the 10-year study period, 177 patients underwent laparoscopic sphincter-preserving TME with curative intent for rectal cancer. Conversion was required in two (1%) patients. There was no operative mortality. At a median follow-up period of 49 months, local recurrence had occurred in nine (5.1%) patients. The overall metastatic recurrence rate after curative resection was 22%. The overall 5-year survival and 5-year disease-free survival in the present study were 74% and 71%, respectively.\n\nConclusion\n\nThe results of this study show that laparoscopic sphincter-preserving TME is safe with long-term oncological outcomes comparable Selleck AZD1208 to those of open surgery.”
“Mesenchymal stem cells (MSCs) from bone marrow have been investigated as the most suitable cell source for bone tissue engineering for their excellent osteogenic potential under the proper conditions. Recently, adipose stem cells (ASCs) have been added to the armentarium as a cell source due to their abundance

and easy accessibility. To develop a strategy to induce osteogenesis from these various stem cells, an understanding of the signaling pathways including key transcription factors regulating osteoblastic differentiation and osteogenic growth factor is essential. In this review, we summarized on these factors and the methods for gene transfer of these factors to enhance osteogenic potentials of adult stem cells as well as brief introduction about bone tissue engineering.”
“Intraspecific competition is a key factor shaping space-use strategies and movement decisions in many species, yet how and when neighbors utilize shared areas while exhibiting active avoidance of one another is largely unknown. Here, we investigated temporal landscape partitioning in a population of wild baboons (Papio cynocephalus).