Disclosure statement We promise that the article is original, is not under consideration, or has not been published previously elsewhere, and its content has not been anticipated by a previous publication. There are no benefits conflicts in any form. Acknowledgements We thank Professor Tong-Chuan He (Laboratory of Molecular Oncology, University of Chicago, USA) for providing us the generous gift HEK 293 cell line. This work was see more supported by the National Natural Science Foundation of China (No.39970768) and in part by
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