Int Rev Cyt 2004, 233:93–134.CrossRef 5. Kawai T, Akira S: Toll-like receptors and their crosstak with other innate receptors in infection and immunity. Immune Int Rev Cytol 2011, 34:637–650. 6. Miao EA, Rajan JV, Aderem A: Caspase-1-induced pyroptotic cell Saracatinib in vitro death. Immunol Rev 2011, 243:206–214.PubMedCrossRef 7. Miao EA, Leaf IA, Treuting PM, Moa DP, Dors M, Sarkar A, Warren SE, Wewers MD, Aderem A: Caspase-1-induced pryoptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 2010, 11:1136–1143.PubMedCrossRef 8. Schmidt CK, Ikeda JS, Darnell SC, Watson PR, Bispham

J, Wallis TS, Weinstein DL, Metcalf ES, O´Brien AD: Absence of all components of the flagellar export and synthesis

machinery differentially alters virulence Idasanutlin cost of Salmonella enterica serovar Typhimurium in models of typhoid fever, survival in macrophages, tissue culture invasiveness, and calf enterocolitis. Infect Immune 2001, 69:5619–5625.CrossRef 9. Van Asten FJ, Hendriks HG, Koninkx JF, Van der Zeijst BA, Gaastra W: Inactivation of the flagellin gene of Salmonella enterica serovar Enteritidis strongly reduces invasion into differentiated Caco-2 cells. FEMS Microbiol Lett 2000, 185:175–179.PubMedCrossRef 10. La Ragione RM, Cooley WA, Velge P, Jepson MA, Woodward MJ: Membrane ruffling and invasion of human and avian cell lines is reduced for aflaggelate mutants of Salmonella enterica serovar Enteritidis. Int J Med Microbiol 2003, 293:261–272.PubMedCrossRef 11. Carsiotis M, Stocker BAD, Weinstein DL, O’Brien AD: Flagella of Salmonella typhimurium are a virulence factor in infected C57BL/6J mice. Infect Immun 1984, 46:814–818.PubMed 12. Lockman HA, Curtiss R 3rd: Virulence of non-type 1-fimbriated and nonfimbriated

nonflagellated Salmonella typhimurium mutants in murine typhoid fever. Infect Immun 1988, 60:491–496. 13. Allen-Vercoe E, Sayers AR, Woodward the MJ: Virulence of Salmonella enterica serovar Enteritidis aflagellate and afimbriate mutants in a day-old chick model. Epidemiol Infect 1999, 122:395–402.PubMedCrossRef 14. Robertson JM, Grant G, Allen-Vercoe E, Woodward MJ, Pusztai A, Flint HJ: Adhesion of Salmonella enterica serovar Enteritidis strains lacking fimbriae and flagella to rat ileal explants cultured at the air interface or submerged in tissue culture medium. J Med Microbiol 2000, 49:691–696.PubMed 15. Robertson JM, McKenzie NM, Duncan M, Allen-Vercoe E, Woodward MJ, Flint HJ, Grant G: Lack of flagella disadvantages Salmonella enterica serovar Enteritdis during the early stages of infection in the rat. J Med Microbiol 2003, 52:91–99.PubMedCrossRef 16. Uzzau S, Brown DJ, Wallis T, Rubino S, Leori G, Bernard S, Casadesús J, Platt DJ, Olsen JE: Host adapted serovars of Salmonella enterica . Epidemiol Infect 2000, 125:229–255.PubMedCrossRef 17.