NAFLD was evaluated
by ultrasound. Testosterone was measured by an immunoassay.
Results: Serum androgen levels and the prevalence of NAFLD (83.3% vs. 26.9%; P<.001) were higher in patients with OSA than those without OSA. The mean apnea-hypopnea index (AHI) was higher in patients with NAFLD than check details in those without NAFLD (16.87 events [ev]/h vs. 1.57 ev/h; P<.002). On multivariate logistic regression, where body mass index >= 30 kg/m(2), homeostasis model assessment for insulin resistance >= 2.7, and OSA (AHI >= 5 ev/h) were independent variables, only OSA was an independent predictor of NAFLD (odds ratio [OR], 7.63; P = .044). Free testosterone levels >= 1.07 ng/dL were also independently associated with OSA (OR, 8.18; P = .023).
Conclusion: In PCOS women, the occurrence of OSA strongly
predisposes them to development of NAFLD and a worse metabolic profile; hence, treatment of OSA might be beneficial for NAFLD.”
“BACKGROUND: Many polycyclic aromatic hydrocarbon (PAH) contaminated sites also contain high levels of toxic heavy metals. The presence of heavy metals can adversely affect PAH biodegradation. LEE011 Encapsulation of bacterial cells has been shown to improve survival and activity of cells under various environmental stresses. This study examined if encapsulation of a phenanthrene-mineralizing bacterial strain could improve its survival and phenanthrene degradation in heavy metal contaminated soils.
RESULTS: Alginate encapsulation did not improve survival and phenanthrene degradation by Pseudomonas sp. UG14Lr in heavy metal contaminated soil. Phenanthrene degradation by, and survival of, free cells and alginate-encapsulated cells were similar
in soil contaminated with 5 mg kg(-1) dry soil of As, Cd, or Pb. The number of UG14Lr cells decreased to undetectable level when the concentration of each heavy metal was increased to 100 mg kg(-1) dry soil. UG14Lr, when inoculated as free cells, survived the best and they were detected over 60 days of incubation in soil. Cells in both wet and dry alginate beads survived less well than free cells at the higher metal concentrations. Correspondingly, phenanthrene degradation in soil inoculated with free UG14Lr was better than that in soil inoculated with alginate-encapsulated cells.
CONCLUSION: Alginate encapsulation LY411575 molecular weight adversely affected the survival and phenanthrene degradation ability of UG14Lr cells in heavy metal contaminated soil. It is postulated that alginate may have concentrated the metals which in turn increased the toxicity to UG14Lr cells. The results are of interest to those interested in the use of encapsulation technology to formulate microbial cells for bioremediation purposes. (C) 2009 Society of Chemical Industry”
“In pregnancy complicated by diabetes periods of hyperglycemia lead to accelerated fetal growth, resulting in a large for gestational age (LGA), or macrosomic, infant.