Neither study found a statistically or clinically significant effect of the intervention on any of the outcome measures which included ankle dorsiflexion range, foot posture, and ankle strength. Interestingly, participants in one of the studies anecdotally reported improvement in

motor activities after wearing the splint (Refshauge et al 2006). Both studies reported SCH772984 concentration technical difficulties with the prefabricated splint falling off at night, which may have resulted in insufficient inhibitors duration or intensity of the stretch (Redmond 2004, Refshauge et al 2006). Serial casting is also employed to increase ankle dorsiflexion range in children and young adults with Charcot-Marie-Tooth disease. Typically, a below-knee cast is applied to lengthen the triceps surae and worn for 24 hours a day. Cast changes are made every three to seven days, each aiming to achieve a greater range of ankle dorsiflexion than the previous cast, and continued until the desired range of ankle dorsiflexion is obtained. Although there have been no randomised trials of serial casting in people with Charcot-Marie-Tooth disease, there have been studies in other neurological conditions such Alpelisib manufacturer as traumatic brain injury (Moseley 1997, Moseley et al 2008). While significant gains in ankle dorsiflexion range occurred in these studies, gains were generally lost once the cast was removed. Clinically, serial casting is not always well tolerated by individuals with Charcot-Marie-Tooth disease. Wearing

casts full-time can be uncomfortable and inconvenient, particularly for more active children and young adults (Refshauge et al 2006). In addition, many people with this disease have sensory impairment, which is thought to increase the risk of developing pressure areas if casts are worn continuously.

In patients at risk of such complications, a removable serial night cast can be fabricated whereby the cast is applied according to the principles of serial casting, but bi-valved and worn only at night. However there are no data to support its use in Charcot-Marie-Tooth disease. Therefore, the specific research question Sitaxentan for this study was: Does 4 weeks of serial night casting followed by 4 weeks of stretching of the gastrocnemius and soleus improve ankle dorsiflexion range, mobility and balance, and reduce foot deformity, falls, and self-reported activity limitations compared with no intervention in children and young adults with Charcot-Marie-Tooth disease? A randomised trial with assessor blinding and intention-totreat analysis was conducted. People with Charcot-Marie-Tooth disease were recruited from the neurogenetics and peripheral neuropathy clinics at a large tertiary children’s hospital in Australia. After baseline measures were collected, the treating physiotherapist telephoned the administrative assistant to obtain the participant’s random allocation. The randomisation sequence was computer-generated by an offsite administrative assistant who had no further involvement in the study.