None of the non-elderly with postoperative hemorrhage had received anticoagulant therapy. In the elderly with postoperative hemorrhage, 15.8% of the lesions were in those who had received anticoagulant therapy, indicating a significantly higher percentage of such lesions in the elderly

group. Conclusion:  We conclude that ESD is useful in elderly patients because there is a similar risk as for the non-elderly if the approach is individualized, and the following are taken into consideration when making the final decision of performing ESD in an elderly patient: patients should have a PS of 0, 1, or 2; determine whether or not selleck chemical anticoagulant therapy can be discontinued and whether or not treatment can be performed reliably without complications. Endoscopic mucosal resection (EMR) is an effective treatment

for early gastric cancer, but it has risks that can affect patient survival if the indication is wrong or the resection is incomplete. Therefore, endoscopic submucosal dissection (ESD) has been used for en bloc resection, which allows more accurate pathological GPCR Compound Library molecular weight diagnosis. ESD for early gastric cancer can achieve a higher en bloc resection rate, even for large lesions, compared with conventional EMR. If the correct indications are used, ESD can be a radical treatment with results comparable to open surgery.1–4 Therefore, ESD is thought to greatly improve the patient’s quality of life (QOL) compared with laparotomy. In Japan, life expectancy is approximately 80 years, and Japan has the longest life expectancy in the world for both men and women.

In its increasingly aged society, a growing number of endoscopic treatments are performed on the elderly (the medically vulnerable) with age-associated comorbidities such as cardiovascular diseases.5,6 Esophagogastroduodenoscopy (EGD) itself can have risks for elderly patients, and further caution CDK inhibitor is particularly needed for those with comorbidities of heart or lung diseases.7–13 ESD requires skill, has a high degree of difficulty, and is reported to have a longer operating time and a higher risk than EMR.1,2 However, ESD is also reported to be a safe and reliable procedure in the stomach and colon for the elderly,14,15 although those reports could have already had a bias at the time ESD was performed on the patients. Indications are determined with consideration for comorbidity, performance status (PS), and survival. However, neither of the reports clearly stated the criteria of indications. In addition, there has not been any report on the relationship between anticoagulant therapy and duration of hospitalization or ESD complications in elderly patients. In the present study, we elucidated the usefulness and problems of ESD for early gastric cancer in elderly patients (≥ 65 years) compared with non-elderly patients.