The advisors assisted in developing the study protocol and the statistical analysis plan, made recommendations on the analysis Alpelisib mouse and

exploitation of the study results and contributed to the writing of the present article. Both received honoraria from the sponsor in return for their participation. Data analysis was performed by Stat-Process, an independent data analysis company working in the field of healthcare, which was responsible for the extraction of the source data from the Thalès database, contributed to the statistical analysis plan and produced the statistical report. Stat-Process received fees from Laboratoire GlaxoSmithKline for its involvement in the study. Laboratoire GlaxoSmithKline also funded the editorial support for the preparation of the present article. The authors thanks Adam Doble (Foxymed, Paris, France) for help in preparing the manuscript. Open Access This article is distributed under the terms of the Creative selleck chemical Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original

author(s) and source are credited. Conflicts of interest C. Roux has received research grants and/or speaker’s fees from Alliance, Amgen, Lilly, MSD, Novartis, GSK-Roche, Servier and Wyeth. References 1. World Health Organization (2003) Adherence to EVP4593 concentration long-term therapies: evidence for action. World Florfenicol Health Organization, Geneva, Switzerland 2. Vik SA, Hogan DB, Patten SB, Johnson JA, Romonko-Slack L, Maxwell CJ (2006) Medication nonadherence and subsequent risk of hospitalisation and mortality among older adults. Drugs Aging 23:345–356CrossRefPubMed 3. Cramer JA, Gold DT, Silverman SL, Lewiecki EM (2007) A systematic review of persistence and compliance with bisphosphonates for osteoporosis. Osteoporos Int 18:1023–1031CrossRefPubMed 4. Lekkerkerker F, Kanis JA, Alsayed

N, Bouvenot G, Burlet N, Cahall D, Chines A, Delmas P, Dreiser RL, Ethgen D, Hughes N, Kaufman JM, Korte S, Kreutz G, Laslop A, Mitlak B, Rabenda V, Rizzoli R, Santora A, Schimmer R, Tsouderos Y, Viethel P, Reginster JY (2007) Adherence to treatment of osteoporosis: a need for study. Osteoporos Int 18:1311–1317CrossRefPubMed 5. Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, Wong PK (2008) Medication compliance and persistence: terminology and definitions. Value Health 11:44–47PubMed 6. Geusens PP, Roux CH, Reid DM, Lems WF, Adami S, Adachi JD, Sambrook PN, Saag KG, Lane NE, Hochberg MC (2008) Drug insight: choosing a drug treatment strategy for women with osteoporosis—an evidence-based clinical perspective. Nat Clin Pract Rheumatol 4:240–248CrossRefPubMed 7. Tosteson AN, Grove MR, Hammond CS, Moncur MM, Ray GT, Hebert GM, Pressman AR, Ettinger B (2003) Early discontinuation of treatment for osteoporosis. Am J Med 115:209–216CrossRefPubMed 8.