The aim of this study was to identify the extent and pattern of cardiac remodeling in a group of severely obese patients and analyze the relationship between adiponectin, IGF-I and cardiac parameters reflecting obesity-associated structural changes. Subjects Pinometostat solubility dmso and methods: Our study included 344 patients (104 men) with severe obesity [mean body mass index (BMI)= 45.7 +/- 8.5 kg/m(2)], extensively evaluated clinically and biologically (complete metabolic tests, serum adiponectin, and IGF-I measurements). Left ventricular (LV) mass index (LVMI), left atrium (LA) size, and LV geometry were determined by means of cardiac ultrasound. Results: The most prevalent pattern of LV geometry was eccentric hypertrophy (28.7%

of patients). In a gender-, age-, BMI-, diabetes-and hypertension-adjusted general linear model, patients with concentric or eccentric hypertrophy had significantly lower values of adiponectin than those with normal geometry (6.75 +/- 0.41, 6.96 +/- 0.53, vs 9.04 +/- 0.42 mg/l, p smaller than 0.05). In multivariate analysis, independent determinants for LVMI were BMI (beta=0.364, p smaller than 0.001), systolic blood pressure (BP) (beta=0.187, p=0.004), age (beta=0.246, p smaller than 0.001), adiponectin (beta=-0.151, p=0.012), and IGF-I z-score (beta=0.134, p=0.025) while factors

independently related to LA size were Vorinostat datasheet systolic BP (beta=0.218, p smaller than 0.001), BMI (beta=0.194, p smaller than 0.001), age (beta=0.273, p smaller than 0.001), gender (beta=-0.195, p smaller than 0.001), and adipo nectin (beta=-0.180, p=0.005). Conclusions: In patients with

severe obesity, IGF-I z score and adiponectin correlate with parameters of cardiac remodeling independently of anthropometric, hemodynamic or metabolic factors. (C) Duvelisib 2013, Editrice Kurtis”
“The objective of this study was to investigate the toxicological effects of dietary NiCl2 on IgA(+) B cells and the immunoglobulins including sIgA, IgA, IgG and IgM in the small intestine and cecal tonsil of broilers by the methods of immunohistochemistry and enzyme-linked immunosorbent assay (ELISA). Two hundred and forty one-day-old avian broilers were randomly divided into four groups and fed on a control diet and three experimental diets supplemented with 300, 600, and 900 mg/kg NiCl2 for 42 days. Compared with the control group, the IgA(+) B cell number and the sIgA, IgA, IgG, and IgM contents in the NiCl2-treated groups were significantly decreased (p smaller than 0.05 or p smaller than 0.01). It was concluded that dietary NiCl2 in the excess of 300 mg/kg had negative effects on the IgA+ B cell number and the abovementioned immunoglobulin contents in the small intestine and the cecal tonsil. NiCl2-reduced sIgA, IgA, IgG and IgM contents is due to decrease in the population and/or the activation of B cell. The results suggest that NiCl2 at high levels has intestinal mucosal humoral immunotoxicity in animals.