The mycological cure rate of the patients treated with nystatin at days 7–14 and days 30–35 in VVC was 85.4% (129/151) and 83.4% (126/151) respectively. We conclude that fluconazole
resistance was rare and both C. albicans and non-albicans Candida species were susceptible to nystatin in vitro. The decrease in fluconazole susceptibility or a low concentration of fluconazole in the vagina was probably related to fluconazole therapeutic failure. “
“Vulvovaginal candidiasis is one of the most frequent disorders in obstetrics and gynaecology. Approximately three-quarters of all adult women experience at least one episode of vulvovaginal CDK and cancer candidiasis during their life span. Diabetes mellitus (DM) increases the rate of vaginal colonisation and infection with Candida species. The secreted acid proteinase might be especially relevant in the pathogenesis of vulvovaginal candidiasis. The aim of this study was to determine the acid proteinase activity in the samples of Candida albicans from diabetic patients with vulvovaginal candidiasis by a fluorometric method. Vaginal swabs were taken from 33 women (aged between 22 and 57 years) having symptoms of vaginitis.
Patients were divided into three groups: control group, controlled diabetic group and uncontrolled diabetic group. The proteinase activity in the culture supernatants was determined by a modified fluorometric method. Acid proteinase activities were significantly increased in the uncontrolled diabetic group in comparison with both the control group and the controlled
diabetic group (P < 0.05). Acid proteinase may play an important role in C. albicans learn more pathogenesis in diabetic patients. Improving glucose control may reduce the risk of Candida colonisation and potentially symptomatic Unoprostone infection, among women with diabetes and hence may be useful even for weaker enzyme activity measurements. “
“Die schwer zu diagnostizierenden Erkrankungen durch Aspergillus spp. erfordern ergänzende serologische Teste. Das ist das Ergebnis selektiver Literatur-Recherche unter Berücksichtigung aktueller Leitlinien. Für die Manifestationsformen der Aspergillose wird derzeit zur Ergänzung der konventionellen Diagnostik (Bildgebung, Mikroskopie und Kultur) die Bestimmung folgender Parameter aus Blutserum empfohlen: Invasive und chronisch-nekrotisierende Aspergillose: Aspergillus-Galactomannan-Antigen. Testformat: EIA auf der Basis des Ratten-MAb EB-A2. Cut-off 0,5 (Index). Überwachung von Hochrisiko-Patienten: 2 x wöchentlich. Aspergillus-IgG (Testformat: EIA) als Bestätigungs-Test bei Rekonstitution der Leukozyten-Funktion unter Therapie. Aspergillom: Aspergillus-IgG (Testformat: EIA). Allergische Aspergillose: Aspergillus-IgE (Testformat: RAST). Der Galactomannan-Antigen-Nachweis hat einen festen Stellenwert in der Diagnostik invasiver Aspergillosen. Die Evaluation von Aspergillus-Nukleinsäure-Amplifikations-Assays steht noch aus. Diseases caused by Aspergillus spp.