The results of sonography and uroflow measures also differed between groups.

Conclusions: Different subtypes

of enuresis and urinary incontinence demonstrate differences in behavioral problems and psychiatric comorbidity. The highest rates of psychiatric comorbidity were found in the group of children with voiding postponement and the lowest were in children with monosymptomatic nocturnal enuresis. We recommend screening for comorbid psychiatric disorders in children with enuresis AR-13324 and urinary incontinence. Further investigations in a larger group of children are necessary.”
“Acute “”silent”" seizures after brain injury are associated with a worsening of patient outcome and are often refractory to anti-epileptic drug (AED) therapy. Necrostatin-1 price In the present study we evaluated topiramate (TPM, 1-30 mg/kg, i.v.) in a rodent model of spontaneous non-convulsive seizure (NCS) activity induced by focal cerebral ischemia. For seizure detection, electroencephalographic (EEG) activity was continuously recorded for 24 h in male Sprague-Dawley rats subjected to permanent middle cerebral artery occlusion (MCAo). Infarct volume, neurological deficit, and NCS were evaluated by an experimenter blinded to the treatment group. All vehicle

treated rats (7/7) exhibited NCS following MCAo. TPM treatment, delivered at 20 min post-occlusion and prior to onset of NCS activity, dose-dependently reduced the incidence of NCS (ED50 = 21.1 mg/kg). The highest dose of TPM tested (30 mg/kg) exhibited maximal reductions of 76% in the number of NCS/rat (vehicle = 22.1 +/- 5.3, TPM = 4.4 +/- 3.2, P < 0.05), 80% in the total time of NCS (vehicle = 1259 +/- 337 s, TPM = 253 +/- 220 s, P < 0.05), 20% in core brain

infarction (vehicle = 45 +/- 1%, TPM = 36 +/- 4%, percent of ipsilateral volume corrected for swelling, P < 0.05), and 38% in neurological deficit score (vehicle = 7.4 +/- 1.2, TPM = 4.6 +/- 1.5, P < 0.05). Despite efficacy as a pre-seizure treatment, TPM was not effective when delivered immediately following onset of the first NCS event (36 +/- 5 min post-MCAo). In conclusion, this website TPM exhibited significant efficacy for the prophylactic treatment of brain-injury induced NCS and represents a novel class of AED for treatment of this type of silent brain seizure. Published by Elsevier Ireland Ltd.”
“Purpose: The Malone antegrade continence enema procedure revolutionized the surgical management of fecal incontinence. Open and laparoscopic antegrade continence enemas are often performed with cecoplication and mesenteric manipulation. Since our initial laparoscopic antegrade continence enema description, we have simplified our technique. We present our series of laparoscopic antegrade continence enema procedures, discuss technique and outcomes, and review the literature.