The RNA chaperone Hfq is important in modulating genes essential

The RNA chaperone Hfq is important in modulating genes essential to stress and IWR-1 research buy virulence in a variety of bacterial pathogens

by binding sRNAs and their mRNA target [14, 51, 59]. Our study is the first to report the role of Hfq in H. influenzae and highlights the impact of Hfq on nutrient acquisition in vitro and infection Stattic cost progression in vivo of this important human pathogen. Acknowledgements This work was supported by Public Health Service Grant AI29611 from the national Institute for Allergy and Infectious Disease. The authors gratefully acknowledge the ongoing support of the Children’s Hospital Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. References 1. Turk DC: The pathogenicity of Haemophilus influenzae TPCA-1 in vivo . J Med Microbiol 1984, 18:1–16.PubMedCrossRef 2. García-Rodríguez JÁ,

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dinucleotide requirements of Haemophilus influenzae and Haemophilus parainfluenzae . J Med Microbiol 1974, 7:359–365.PubMedCrossRef 6. Herbert M, Kraiss A, Hilpert AK, Schlor S, Reidl J: Aerobic growth deficient Haemophilus influenzae mutants are non-virulent: implications on metabolism. Int J Med Microbiol 2003, 293:145–152.PubMedCrossRef 7. Genco CA, Dixon DW: Emerging strategies in microbial haem capture. Mol Microbiol 2001, 39:1–11.PubMedCrossRef 8. Schaible UE, Kaufmann SH: Iron and microbial infection. Nat Rev Microbiol 2004, PRKACG 2:946–953.PubMedCrossRef 9. Morton D, Stull T: Haemophilus. In Iron Transport in Bacteria. Edited by: Crosa JH, Mey AR, Payne SM. Washington, D.C: American Society for Microbiology; 2004:273–292. 10. Whitby PW, Seale TW, VanWagoner TM, Morton DJ, Stull TL: The iron/heme regulated genes of Haemophilus influenzae : comparative transcriptional profiling as a tool to define the species core modulon. BMC Genomics 2009, 10:6.PubMedCrossRef 11. Whitby PW, Vanwagoner TM, Seale TW, Morton DJ, Stull TL: Transcriptional profile of Haemophilus influenzae : effects of iron and heme. J Bacteriol 2006, 188:5640–5645.PubMedCrossRef 12.

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