There were 48 pts with bleeding GDC-0199 cost ulcer. Age, gender, tobacco and alcohol use didn’t affect the bleeding rate. The risk of bleeding didn’t depend on concomitant diseases (p = 0.509) and exposure to stress (p = 0.944). The history of gastritis was significantly different among investigated groups; bled, 10/48 (20.8%) patients compared with 19/47 (40.4%) patients who didn’t bleed, but also earlier treated gastritis (p = 0,038). Antrum atrophy was found in 14/48 (29.2%) pts with bleeding ulcer and in only

5/47 (10.6%) pts who had ulcer without bleeding (p = 0.024). Patients with BRI < 14 bled in 79.2% and didn't bleed in 57.4% of the cases (p = 0.023). Patients with H2 blockers bled in 10/48 (20.8%) and didn't bleed in 18/47 (38.3%) (p = 0.01). Abnormal platelet function had 12/48 (25.0%) pts who bled,

as opposed to 2/47 (4.3%) pts who didn’t bleed (p = 0.004). The risk of bleeding didn’t depend of blood groups and fluctuating range of vWf. Conclusion: Male gender, cigarette smoking, previous treatment of duodenal ulcer, histopathologically confirmed intestinal metaplasia of the gastric antrum mucosa were risk factor for H.pylori-negative and NSAIDs-negative ulcer disease. Abnormal platelet function (regardless of whether it was a disorder caused by taking RG7204 concentration Aspirin and / or other drugs) and histopathologically confirmed atrophy of the gastric antral mucosa were risk factors for “idiopathic” ulcer bleeding. The protective effect on “idiopathic” ulcer bleeding was significantly higher among H2 blocker users, patients with previous treatment of gastritis and the high bile reflux index. Key Word(s): 1. idiopathic; 2. peptic ulcer; 3. no-H.pylori, NSAID; 4. bleeding; Presenting Author: WEI-YI LEI Additional Authors: WEN-LIN LO, TSO-TSAI LIU, CHIH-HSUN YI, CHIEN-LIN CHEN Corresponding Author: WEI-YI LEI Affiliations: Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan Objective: Achalasia is characterized by esophageal aperistalsis and failure of lower esophageal sphincter MCE (LES) relaxation. Combined multichannel intraluminal impedance and manometry (MII-EM) allows simultaneous recording of esophageal

peristalsis and bolus transport patterns. The aim of this study was to evaluate the feasibility of MII-EM for the assessment of esophageal motility and characterize patterns of esophageal bolus transport in patients with achalasia and those after Heller myotomy. Methods: A total of nine patients (two men and seven women, range 25 to 46 years) were enrolled in this study. Two of the patients underwent Heller myotomy in the past. All patients underwent combined MII-EM with a nine channel esophageal function testing catheter containing four impedance-measuring segments and five solid-state pressure transducers. Each patient received ten liquid and ten viscous swallows in a sitting position. All tracings were recorded and analyzed for esophageal contractions and bolus transit.