We report the feasibility and implications of an ICG colour imaging system, HyperEye Medical System (HEMS), in surgeries for arteriosclerosis
obliterans (ASO) and abdominal aortic aneurysm (AAA) which carry risk of mesenteric ischaemia.
Methods: HEMS ICG angiography was used for the intra-operative assessment of 12 ASO patients and 10 AAA patients.
Results: In the ASO patients, HEMS angiography enabled visualisation of the graft and native artery. The fluorescent find more lucent region in the artery distal to the anastomosis was shown in -1 of 12 ASO patients. There was a 3-s time lag in the increase of intensity between the proximal artery and distal stenotic region. In AAA patients, HEMS angiography clearly showed the perfusion in the mesenteric GNS-1480 clinical trial arteries and intestinal wall as opaque. One AAA patient had segmental ischaemia due to thromboembolism and another one had diffuse ischaemia due to systemic malperfusion. The ischaemic region of the intestine was visualised
as a fluorescent lucent area by HEMS angiography.
Conclusion: HEMS angiography can accurately assess peripheral arterial perfusion in surgical cases with ASO and AAA. (C) 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.”
“Seminal studies in rabbits and rodent transplantation models by Peter Medawar revealed that cellular processes, rather than humoral antibodies, are central to the acute rejection of transplanted organs, and much of basic transplantation research continues to be focused on the biology and control of these cells, which were subsequently shown to be T cells. However, the success of current immunosuppression at controlling T-cell-mediated
rejection has resulted NVP-BSK805 in an increasing awareness of antibody-mediated rejection in the clinic. This, in turn, has fueled an emerging interest in the biology of allospecific antibodies, the B cells that produce these antibodies, and the development of mouse models that allow their investigation. Here we summarize some of the more widely used mouse models that have been developed to study the immunobiology of alloreactivity, transplantation rejection and tolerance, and used to identify therapeutic strategies that modulate these events.”
“Objective The increasing importance of canine retinal dystrophy models means accurate vision testing is needed. This study was performed to evaluate a four-choice vision testing technique for any difference in outcome measures with repeated evaluations of the same dogs. Animals studied Four 11-month-old RPE65-deficient dogs. Procedures Vision was evaluated using a previously described four-choice vision testing device. Four evaluations were performed at 2-week intervals.